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Targeted Radionuclide Therapy

Targeted Radionuclide Therapy

9780781796934
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Description

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion.

A companion website includes the full text and an image bank.

Product Details
Lippincott Williams & Wilkins
48126
9780781796934
9780781796934

Data sheet

Publication date
2010
Issue number
1
Cover
hard cover
Pages count
608
Dimensions (mm)
213 x 276
Weight (g)
1565

  • Part I:: IMMUNOLOGY AND TARGETING CONSTRUCTS

    1:: The Immune System

    2:: Methods for Development of Monoclonal Antibody Therapeutics

    3:: Peptides

    4:: Affibody Molecules for Targeted Radionuclide Therapy

    5:: Aptamers

    Part II:: PHYSICS AND RADIOBIOLOGY OF TRT

    6:: The Physics and Radiobiology of TRT

    7:: Chelation Chemistry

    8:: Radiation Dosimetry

    9:: Microdosimetry

    10:: Radiation Safety for RT

    Part III:: TUMOR MICROENVIRONMENT AND DELIVERY STRATEGIES

    11:: Employing SEREX

    12:: Antibody Penetration into Tumors

    13:: Overcoming Barriers Posed by Solid Tumors

    14:: The Delivery Construct

    15:: The Type of Radionuclide

    16:: Pretargeting Strategies for TRT

    17:: Combined Modality Strategies

    18:: Extracorporeal Techniques

    19:: Concept of Systemic Therapy

    20:: Modeling of the Systemic Cure with TRT

    Part IV:: UNCONJUGATED THERAPY

    21:: Thyroid Cancer

    22:: Unconjugated Radiopharmaceuticals

    23:: 90-y Microspheres

    24:: SIRT

    Part V:: CONJUGATED THERAPY

    25:: Colorectal Cancer

    26:: Pancreatic Cancer

    27:: Hepatobillary Cancer

    28:: Astrocytoma

    29:: Medullary Thyroid Cancer

    30:: Head and Neck Cancer

    31:: Prostate Cancer

    32:: Renal Cell Carcinoma

    33:: Bladder Cancer

    34:: Leukemia

    35:: Non-Hodgkins Lymphoma

    36:: Hodgkins Disease

    37:: Multiple Myeloma

    38:: Neuroendocrine Tumors

    39:: Malignancies Treated with Peptides

    40:: Ovarian Cancer

    41:: Osteosarcoma

    42:: Pediatric Tumors

    43:: Palliation

    44:: Melanoma

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