Principles and Practice of Pediatric Oncology

xvi Preface

xvii

Chapter 1 Epidemiology of Childhood Cancer 2

Michael E. Scheurer, Melissa L. Bondy, and James G. Gurney

Chapter 2 Childhood Cancer and Heredity 17

Sharon E. Plon and David Malkin

Chapter 3 Molecular and Genetic Basis of Childhood Cancer 38

Peter D. Aplan and Javed Khan

Chapter 4 Biology of Childhood Cancer 78

Christopher Denny and Kathleen Sakamoto

Chapter 5 Tumor Immunology and Pediatric Cancer 97

Crystal L. Mackall and Paul M. Sondel BIOLOGICAL BASIS OF CHILDHOOD CANCER

Chapter 6 Clinical Assessment and Differential Diagnosis of the

Child with Suspected Cancer 123

Lindsay B. Kilburn, Marcio H. Malogolowkin, John J. Quinn,

Stuart E. Siegel, and C. Philip Steuber

Chapter 7 Pathology and Molecular Diagnosis of Leukemias

and Lymphomas 138

Amy Heerema-McKenney, Michael L. Cleary, and Daniel A. Arber

Chapter 8 Diagnostic Pathology of Pediatric Malignancies 164

Timothy J. Triche, John Hicks, and Poul H.B. Sorensen

Chapter 9 Imaging Studies in the Diagnosis and Management

of Pediatric Malignancies 216

R. Paul Guillerman, Mary E. (Beth) McCarville, Sue C. Kaste,

Barry L. Shulkin, and Stephan D. VossOF MULTIMODAL THERAPY

Chapter 10 General Principles of Chemotherapy 279

Peter C. Adamson, Rochelle Bagatell, Frank M. Balis, and Susan M. Blaney

Chapter 11 Molecularly Targeted Therapies and Biotherapeutics 356

Malcolm A. Smith

Chapter 12 General Principles of Surgery 386

Christopher B. Weldon, Tom Jaksic, and Robert C. Shamberger

Chapter 13 General Principles of Radiation Oncology 406

Larry E. Kun

Chapter 14 Cell and Gene Therapies 426

Stephen Gottschalk, Cliona M. Rooney, and Malcolm K. Brenner

Chapter 15 Infants and Adolescents with Cancer:: Special Considerations 446

Zoann Dreyer, Daniel J. Indelicato, Gregory H. Reaman,

and W. Archie Bleyer

Chapter 16 Hematopoietic Stem Cell Transplantation in

Pediatric Oncology 467

Catherine M. Bollard, Robert A. Krance, and Helen E. Heslop

Chapter 17 Cancer Clinical Trials:: Design, Conduct, Analysis, and Reporting 491

Susan Hilsenbeck, Lisa R. Bomgaars, and Stacey L. Berg

Chapter 18 Regulating Patient Safety in Cancer Treatment 508

Brigitta U. Mueller and Amy L. Billett

Chapter 19 Acute Lymphoblastic Leukemia 518

Judith F. Margolin, Karen R. Rabin, C. Philip Steuber,

and David G. Poplack

Chapter 20 Acute Myeloid Leukemia, Myeloproliferative and

Myelodysplastic Disorders 566

Todd M. Cooper, Henrik Hasle, and Franklin O. Smith

Chapter 21 Chronic Leukemias of Childhood 611

Arnold J. Altman and Cecilia Fu

Chapter 22 Hodgkin Lymphoma 638

Monika Metzger, Matthew J. Krasin, Melissa M. Hudson, and Mihaela Onciu

Chapter 23 Malignant Non-Hodgkin Lymphomas in Children 663

Thomas G. Gross and Sherrie L. Perkins

Chapter 24 Lymphoproliferative Disorders and Malignancies

Related To Immunodeficiencies 683

Bruce Shiramizu, Robert Wilkinson, and Robert Hayashi

Chapter 25 Histiocytic Diseases 703

Kenneth L. McClain, Carl E. Allen, and John Hicks

Chapter 26 Tumors of the Central Nervous System 717

Chapter 26A Gliomas, Ependymomas, and Other Nonembryonal Tumors 717

Susan M. Blaney, Daphne Haas-Kogan, Tina Young Poussaint,

Mariarita Santi, Richard Gilbertson, Donald “Will” Parsons, and Ian PollackF COMMON CANCERS OF

Chapter 26B Embryonal and Pineal Region Tumors 772

Roger J. Packer, Lucy B. Rorke-Adams, Ching C. Lau,

Michael D. Taylor, Gilbert Vezina, and Larry E. Kun

Chapter 27 Retinoblastoma 809

Richard L. Hurwitz, Carol L. Shields, Jerry A. Shields,

Patricia Chévez-Barrios, Dan Gombos, Mary Y. Hurwitz,

and Murali M. Chintagumpala

Chapter 28 Pediatric Liver Tumors 838

Rebecka L. Meyers, Daniel C. Aronson, Dietrich Von Schweinitz,

Arthur Zimmermann, Marcio H. Malogolowkin

Chapter 29 Renal Tumors 861

Conrad Fernandez, James I. Geller, Peter F. Ehrlich,

D. Ashley Hill, John A. Kalapurakal, Paul E. Grundy,

and Jeffrey S. Dome

Chapter 30 Neuroblastoma 886

Garrett M. Brodeur, Michael D. Hogarty, Yael P. Mosse,

and John M. Maris

Chapter 31 Rhabdomyosarcoma 923

Leonard H. Wexler, William H. Meyer, and Lee J. Helman

Chapter 32 The Nonrhabdomyosarcoma Soft Tissue Sarcomas 954

M. Fatih Okcu, Alberto S. Pappo, John Hicks, Lynn Million,

Richard J. Andrassy, and Sheri L. Spunt

Chapter 33 Ewing Sarcoma 987

Douglas S. Hawkins, Tobias Bölling, Steven Dubois,

Pancras C.W. Hogendoorn, Heribert Jürgens, Michael Paulussen,

R. Lor Randall, and Stephen L. Lessnick

Chapter 34 Osteosarcoma:: Biology, Diagnosis, Treatment,

and Remaining Challenges 1015

Richard Gorlick, Stefan Bielack, Lisa Teot, James Meyer,

R. Lor Randall, and Neyssa Marina

Chapter 35 Germ Cell Tumors 1045

Thomas A. Olson, Dominik T. Schneider, and Elizabeth J. Perlman

Chapter 36 Endocrine Tumors 1068

Steven G. Waguespack, Andrew J. Bauer, Winston Huh, and Anita K. Ying

Chapter 37 Management of Infrequent Cancers of Childhood 1098

Alberto S. Pappo, Carlos Rodriguez-Galindo, and Wayne L. Furman

Chapter 38 Oncologic Emergencies 1125

Michael J. Fisher and Susan R. Rheingold

Chapter 39 Hematologic Supportive Care for Children with Cancer 1152

Anurag K. Agrawal, Caroline A. Hastings, and James Feusner

Chapter 40 Infectious Complications in Pediatric Cancer Patients 1190

Andrew Y. Koh and Philip A. Pizzo

Chapter 41 Nutritional Supportive Care 1243

Sonia Arora Ballal, Lori J. Bechard, Tom Jaksic, and Christopher Duggan

Chapter 42 Pain and Symptom Management 1256

Elliot J. Krane, Jacqueline Casillas, and Lonnie K. Zeltzer

Chapter 43 Nursing Support of the Child with Cancer 1288

Marilyn J. Hockenberry and Nancy E. Kline

Chapter 44 Rehabilitation of the Child with Cancer 1305

David W. Pruitt, Mary A. McMahon, Stephanie R. Ried,

Susan D. Apkon, and Linda J. Michaud

Chapter 45 Psychiatric and Psychosocial Support for the Child and Family 1322

Lori S. Wiener, Stephen P. Hersh, and Melissa A. Alderfer

Chapter 46 Ethical Considerations in Pediatric Oncology 1347

Steven Joffe, Jennifer Kesselheim, and Susan B. Shurin

Chapter 47 Late Effects of Childhood Cancer and Its Treatment 1368

Saro H. Armenian, Anna T. Meadows and Smita Bhatia

Chapter 48 Educational Issues for Children with Cancer 1388

Laurie D. Leigh and Heather M. Conklin

Chapter 49 Palliative Care for the Child with Cancer 1404

Christina Ullrich, Barbara Sourkes, and Joanne Wolfe

Chapter 50 Economic Issues in Pediatric Cancer 1428

Susan K. Parsons, Joshua T. Cohen, and Melissa L. Lichte

Chapter 51 Pediatric Cancer:: Advocacy, Insurance, Education, and Employment 1441

Susan L. Weiner, Gilbert P. Smith, Grace P. Monaco, and Joseph Fay

Chapter 52 Complementary and Alternative Medical Therapies in

Pediatric Oncology 1451

Thomas W. McLean and Kathi J. Kemper

Chapter 53 Pediatric Oncology in Countries with Limited Resources 1463

Ronald Barr, Federico Antillon, Bharat Agarwal, Parth Mehta, and Raul Ribeiro

Chapter 54 Preventing Cancer in Adulthood:: Advice for the Pediatrician 1474

Brad H. Pollock and Gail E. Tomlinson

Chapter 55 Resources for Children with Cancer, their Families, and Physicians 1489

Cheryl C. Rodgers

Index 1509