Radiation medicine has evolved on several fronts over the past decade and is a useful adjunct in the definitive, adjunctive, and palliative therapy for several solid and hematologic malignancies. This issue coupled with the Part II publishing in April 2006 should de-mystifyand update the practicing oncologists on how best to incorporate the radiation medicine team into the evaluation and management of patients. Those who can benefit from these issues:: medical oncologists, hematologists, radiation oncologists, family medicine and internal medicine physicians, nurse oncologists, medical social workers, medical physicists, and housestaff/fellows from a myriad of specialties. Key words:: Radiation, medicine, oncology, therapeutic radiology, palliative, stereotactic, radiosurgery, medical physics, combined-modality, quality of life, outcomes