In this issue of Neurosurgery Clinics, guest editors Drs. Jimmy Yang and R. Mark Richardson bring their considerable expertise to the topic of Epilepsy Surgery:: Paradigm Shifts. Top experts in the field explore the underutilization of epilepsy surgery as a public health crisis, and recent paradigm shifts in how epilepsy surgery is conceptualized that may help bring significant improvement to greater numbers of people with drug-resistant epilepsy.