Neuro-oncology Part 3, Neurological Disorders in Systemic Cancer

This volume, the third part of Neuro-Oncology is, in a comprehensive and multidisciplinary approach, devoted to the theme of Neurological Disorders in Systemic Cancer, focusing on issues confronting neurologists in their daily practice. Metastatic disease of the nervous system afflicts about a quarter of all patients with cancer. One chapter is devoted entirely to the origin and mechanisms causing metastatic disease of the nervous system. The neurological complications of hematological neoplasms, including the leukemias, lymphomas, and paraproteinemias, are reviewed in depth, as is the stunning progress made in unravelling the mechanisms of paraneoplastic syndromes of the nervous system. For this intriguing group of disorders, separate attention has been paid to the underlying changes in molecular biology, to the general diagnostic approach and to the characteristics of each of the paraneoplastic syndromes of the central and peripheral nervous system, often associated with specific tumors. All aspects of these disorders are extensively covered in this volume, providing the reader with a working knowledge and useful reference system for understanding the spectrum of neurological disorders that may develop in systemic cancer. Neuro-Oncology will assist the clinical neurologist and other specialists dealing with nervous system complications of cancer in arriving at a well-defined diagnosis and establishing an effective and thoughtful management plan.