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Principles of Neural Science, Sixth Edition (IE)

Principles of Neural Science, Sixth Edition (IE)

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The gold standard of neuroscience texts—updated with hundreds of brand-new images and fully revised content in every chapter 

With 300 new illustrations, diagrams, and radiology studies including PET scans, Principles of Neural Science, 6th Edition is the definitive guide for neuroscientists, neurologists, psychiatrists, students, and residents. Highly detailed chapters on stroke, Parkinsons, and MS build your expertise on these critical topics. Radiological studies the authors have chosen explain whats most important to know and understand for each type of stroke, progressive MS, or non-progressive MS.


  • 2,200 images, including 300 new color illustrations, diagrams, and radiology studies (including PET scans)
  • NEW:: This edition now features only two contributors per chapter and are mostly U.S.-based
  • NEW:: Number of chapters streamlined down from 67 to 60
  • NEW:: Chapter on Navigation and Spatial Memory
  • NEW:: New images in every chapter!

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  • Part I: Overall Perspective
    Chapter 1: The Brain and Behavior
    Chapter 2: Genes and Behavior
    Chapter 3: Nerve Cells, Neural Circuitry, and Behavior
    Chapter 4: The Neuroanatomical Bases by Which Neural Circuits Mediate Behavior
    Chapter 5: The Computational Bases of Neural Circuits That Mediate Behavior
    Chapter 6: Imaging and Behavior

    Part II: Cell and Molecular Biology of Cells of the Nervous System
    Chapter 7: The Cells of the Nervous System
    Chapter 8: Ion Channels
    Chapter 9: Membrane Potential and the Passive Electrical Properties of the Neuron
    Chapter 10: Propagated Signaling: The Action Potential

    Part III: Synaptic Transmission
    Chapter 11: Overview of Synaptic Transmission
    Chapter 12: Directly Gated Transmission: The Nerve-Muscle Synapse
    Chapter 13: Synaptic Integration in the Central Nervous System
    Chapter 14: Modulation of Synaptic Transmission and Neuronal Excitability: Second Messengers
    Chapter 15: Transmitter Release
    Chapter 16: Neurotransmitters

    Part IV: Perception
    Chapter 17: Sensory Coding
    Chapter 18: Receptors of the Somatosensory System
    Chapter 19: Touch
    Chapter 20: Pain
    Chapter 21: The Constructive Nature of Visual Processing
    Chapter 22: Low-Level Visual Processing: The Retina
    Chapter 23: Intermediate-Level Visual Processing and Visual Primitives
    Chapter 24: High-Level Visual Processing: From Vision to Cognition
    Chapter 25: Visual Processing for Attention and Action
    Chapter 26: Auditory Processing by the Cochlea
    Chapter 27: The Vestibular System
    Chapter 28: Auditory Processing by the Central Nervous System
    Chapter 29: Smell and Taste: The Chemical Senses

    Part V: Movement
    Chapter 30: Principles of Sensorimotor Control
    Chapter 31: The Motor Unit and Muscle Action
    Chapter 32: Sensory-Motor Integration in the Spinal Cord
    Chapter 33: Locomotion
    Chapter 34: Voluntary Movement: Motor Cortices
    Chapter 35: The Control of Gaze
    Chapter 36: Posture
    Chapter 37: The Cerebellum
    Chapter 38: The Basal Ganglia
    Chapter 39: Brain–Machine Interfaces

    Part VI: The Biology of Emotion, Motivation, and Homeostasis
    Chapter 40: The Brain Stem
    Chapter 41: The Hypothalamus: Autonomic, Hormonal, and Behavioral Control of Survival
    Chapter 42: Emotion
    Chapter 43: Motivation, Reward, and Addictive States
    Chapter 44: Sleep and Wakefulness

    Part VII: Development and the Emergence of Behavior
    Chapter 45: Patterning the Nervous System
    Chapter 46: Differentiation and Survival of Nerve Cells
    Chapter 47: The Growth and Guidance of Axons
    Chapter 48: Formation and Elimination of Synapses
    Chapter 49: Experience and the Refinement of Synaptic Connections
    Chapter 50: Repairing the Damaged Brain
    Chapter 51: Sexual Differentiation of the Nervous System

    Part VIII: Learning, Memory, Language and Cognition
    Chapter 52: Learning and Memory
    Chapter 53: Cellular Mechanisms of Implicit Memory Storage and the Biological Basis of Individuality
    Chapter 54: The Hippocampus and the Neural Basis of Explicit Memory Storage
    Chapter 55: Language
    Chapter 56: Decision-Making and Consciousness

    Part IX: Diseases of the Nervous System
    Chapter 57: Diseases of the Peripheral Nerve and Motor Unit
    Chapter 58: Seizures and Epilepsy
    Chapter 59: Disorders of Conscious and Unconscious Mental Processes
    Chapter 60: Disorders of Thought and Volition in Schizophrenia
    Chapter 61: Disorders of Mood and Anxiety
    Chapter 62: Disorders Affecting Social Cognition: Autism Spectrum Disorder
    Chapter 63: Genetic Mechanisms in Neurodegenerative Diseases of the Nervous System
    Chapter 64: The Aging Brain

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