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Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies

9780197549469
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Description

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered download from OUP and selected open access locations.

Jaspers Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation.

This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

  • This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence.
  • Definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions
  • Considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures in 79 chapters
  • The perfect guide for every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for clinical reference and board exam preparation
Product Details
OUP USA
98741
9780197549469

Data sheet

Publication date
2024
Issue number
5
Cover
hard cover
Pages count
1712
Dimensions (mm)
178 x 254

  • PREFACE
    DEDICATION
    ACKNOWLEDGMENTS
    SECTION 1 - EVOLVING CONCEPTS
    1. The Paroxysmal Depolarizing Shift (PDS): The First Cellular Marker of Focal Epileptogenesis
    David Prince and Massimo Avoli
    2. Hippocampal Sclerosis in Temporal Lobe Epilepsy: New Views and Challenges
    Carolyn Houser
    3. Cerebral Cortical Dysplasia or Dysgenesis: Keratan Sulfate Proteoglycan for Fetal Axonal Guidance and Excitatory/Inhibitory Synaptic Targets that Influence Epileptogenesis
    Harvey Sarnat and Laura Flores-Sarnat
    4. mTOR in Acquired and Genetic Models of Epilepsy
    Michael Wong, Angelique Bordey, and Steve C. Danzer
    5. Epilepsy Genomics: Disease Causing Sequence Variants
    Antonio Delgado-Escueta
    SECTION 2 - SEIZURES, NETWORKS & SYSTEMS
    Editor: Massimo Avoli; Associate Editors: Christophe Bernard and Marco de Curtis
    Introduction
    Massimo Avoli, Marco de Curtis, Christophe Bernard, and Ivan Soltesz
    6. GABAa-Receptor Signaling and Ionic Plasticity in the Generation and Spread of Seizures
    Kai Kaila, Andrew Trevelyan, Joseph Raimondo, Tommi Ala-Kurikka, Gilles Huberfeld, Massimo Avoli, and Marco de Curtis
    7. Connexins, Pannexins and Epilepsy
    Liang Zhang, Georg R. Zoidl, and Peter L. Carlen
    8. Mechanisms Leading to Initiation, Development and Termination of Focal Seizures
    Marco de Curtis, Piotr Suffczynski, Maxime Lévesque, Laura Librizzi,Laura Uva, Paolo Scalmani, Vadym Gnatkovsky, and Massimo Avoli
    9. Transition to Seizure from Cellular, Network, and Dynamical Perspectives
    Wei-Chih Chang, Jan Kudlacek, Premysl Jiruska, and John G.R. Jefferys
    10. Role of the Subiculum in Focal Epilepsy
    Alesya Evstratova, Belén Diaz-Fernandez, Maxime Lévesque, Massimo Avoli, and Gand illes Huberfeld
    11. Optogenetic Modulation of Focal Seizures
    Maxime Lévesque, Massimo Avoli, and Merab Kokaia
    12. Balancing Seizure Control with Cognitive Side-Effects
    Sheela Tropani, Gene G Gurkoff, Kiarash Shahlaie, Fady Girgis, Ignacio Saez, Jeffrey Kennedy, and Karen A Moxon
    13. High Frequency Oscillations
    Liset Menendes de la Prida and Jean Gotman
    14. Seizures and Sleep
    Birgit Frauscher and Igor Timofeev
    15. Cycles in epilepsy
    Maxime Baud, Vikram Rao, Christophe Bernard, and Philippa Karoly
    16. Human Single Unit Recordings in Epilepsy
    Edward Merricks and Catherine Schevon
    17. Role of Ion Concentration Dynamics in Epileptic Seizures
    Oscar C González, Igor Timofeev, and Maxim Bazhenov
    18. A Classification of Seizures Based on Dynamics
    Hiba Sheheitli, Huifang Wang, Jean-Didier Lemarechal, Christophe Bernard, and Viktor K. Jirsa
    19. Seizures, Networks & Systems - Computational EEG Analysis of Human Epileptogenic Networks
    Vadim Gnatkovsky and Kaspar Schindler
    20. Excitation-Inhibition Balance in Absence Seizure Ictogenesis
    Magor L. Lorincz, Vincenzo Crunelli, and Francois David
    21. Cortical and Thalamic PV+ Interneuron Dysfunction in the Pathogenesis of Absence Epilepsy
    Jochen Meyer and Atul Maheshwari
    22. Convergence of Thalamic Mechanisms in Genetic Epilepsies
    Frances Cho and Jeanne Paz
    Section 3 - EPILEPTOGENESIS: MOLECULAR MECHANISMS & TREATMENTS
    Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and David Henshall
    Introduction
    Annamaria Vezzani and Helen Scharfman
    23. The Diverse Roles of Mossy Cells in the Normal Brain, Epileptogenesis, and Chronic Epilepsy
    Helen Scharfman
    24. Temporal Lobe Epileptogenesis; A Focus on Etiology, Neuron Loss, The Latent Period, and Dentate Granule Cell Disinhibition
    Robert Sloviter
    25. Adult Neurogenesis in Epileptogenesis and Comorbidities
    Kyung-Ok Cho and Jenny Hsieh
    26. A Crucial Role for Astrocytes in Epileptogenesis: Gap Junctions and Glutamate Receptors
    Peter Bedner, Allison R. Peterson, DevinK.Binder, Christian Steinhäuser
    27. Adenosine Kinase: Cytoplasmic and Nuclear Isoforms
    Madhuvika Murugan and Detlev Boison
    28. Inflammatory Astrocytic TGFß- Signaling Induced by Blood-Brain Barrier Dysfunction Drives Epileptogenesis
    Lynn T. Yang, Giovanni Anthony, and Daniela Kaufer
    29. Pericytes and Microglia: Neurovascular and Immune Regulatory Cells in Seizure Disorders
    Nicola Marchi and Amy Brewster
    30. Neuroinflammation in Epilepsy: Cellular and Molecular Mechanisms
    Ray Dingledine, Nicholas Varvel, Teresa Ravizza, and Annamaria Vezzani
    31. Role of Reactive Oxygen Species in Epilepsy
    Ashwini Sri Hari, Matthew C. Walker, and Manisha Patel
    32. BDNF/TrkB Signaling and Epileptogenesis
    Stephen Harward, Yang Huang, and James McNamara
    33. Clinical Features and Molecular Mechanisms Underlying Autoantibody-Mediated Seizures
    Alexander Mathy and Sarosh Irani
    34. Transcriptomic Alterations in Epileptogenesis: Transcription Factors in the Spotlight
    Gary Brennan and Karen van Loo
    35. Epigenetics
    Katja Kobow and Nadia Khan
    SECTION 4 - BIOMARKERS OF EPILEPTOGENESIS
    Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and David Henshall
    Introduction
    Annamaria Vezzani and David Henshall
    36. EEG Biomarkers of Epileptogenesis
    Lyna Kamintsky, Dan Z Milikovsky, and Alon Friedman
    37. Blood Biomarkers: Noncoding RNAs and Proteins
    David Henshall and Michele Simonato
    38. Behavioural Biomarkers of Epileptogenesis and Epilepsy Severity
    Idrish Ali, Pablo Casillas-Espinosa, Nigel Jones, and Terence OBrien
    39. Genetic and Imaging Biomarkers of Epileptogenesis
    Matthias Koepp, Simona Balestrini, Stefanie Dedurwaerdere, and William Theodore
    40. Machine-Learning Approach to Discover Novel Biomarkers for Post-Traumatic Epilepsy
    Robert Ciszek, Eppu Manninen, Olli Gröhn, Jussi Tohka, and Asla Pitkänen
    SECTION 5 - GENES AND NETWORK DEVELOPMENT
    Editors: Antonio Delgado Escueta and Jeffrey Noebels; Associate Editor: Elsa Rossignol
    Introduction
    Jeffrey Noebels
    41. Human Epilepsy Gene Discovery: The Next Decade
    Emily Bonkowski and Heather Mefford
    42. Functional Exploration of Epilepsy Genes in Patint-Derived Cells
    Maria Carmen Varela, Ranmal Samarasinghe, and Jack Parent
    43. Brain mosaicism in Epileptogenic Cortical Malformations
    Théo Ribierre and Stéphanie Baulac
    44. Sodium Channelopathies in Human and Animal Models of Epilepsy and Neurodevelopmental Disorders
    Kazuhiro Yamakawa, Miriam Meisler, and Lori Isom
    45. Potassium Channels in Genetic Epilepsy: a Functional Perspective
    Matthew Weston and Anastasios Tzingounis
    46. High Voltage Activated Calcium Channels in Epilepsy: Lessons from Humans and Rodents
    Elsa Rossignol
    47. Transcription Factors Regulating Interneuron Development
    Emily Ling-Lin Pai, Daniel Vogt, Jia Sheng Hu, and John Rubenstein
    48. GABAA Receptors, Seizures and Epilepsy
    Richard Olsen, Martin Wallner, and Michael A. Rogawski
    49. Gene genome interactions - Understanding complex molecular traits in epilepsy
    Katja Kobow and John Mahoney
    SECTION - 6 PROGRESSIVE MYOCLONUS EPILEPSIES
    Editor: Antonio Delgado-Escueta; Associate Editor: Berge Minassian
    Introduction
    A.V. Delgado-Escueta, Berge Minassian, Jose M Seratossa
    50. The Neuronal Ceroid Lipofuscinoses
    Sara Mole
    51. Progressive Myoclonus Epilepsy: Unverricht-Lundborg Disease
    Saara Tegelberg, Tarja Joensuu, and Anna-Elina Lehesjoki
    52. Strategies on Gene Therapy in Progressive Myoclonus Epilepsies
    Saima Kayani, Emrah Gumusgoz, Berge Minassian, and Alison Dolce
    53. Therapeutic Window for the Treatment of Lafora Disease
    Olga Varea, Joan Guinovart, and Jordi Duran
    54. Progressive Myoclonus Epilepsy of Lafora- Treatment with Metformin
    Jose M. Seratossa, Daniel F. Burgos, Luis Zafra-Puerta, Nerea Iglesias-Cabeza, Pascual Sanz, and Marina P. Sánchez
    55. Treating Lafora Disease with an Antibody-Enzyme Fusion
    Matthew Gentry, Kia H. Markussen, Ramon Sun, and Craig W. Vander Kooi
    56. Antisense Oligonucleotide Therapy for Progressive Myoclonus Epilepsies
    Silvia Nitschke and Berge Minassian
    SECTION 7 - COMORBIDITIES OF EPILEPTIC NETWORKS
    Editor: Jeffrey Noebels; Associate Editor: Peyman Golshani
    Introduction
    Jeffrey Noebels
    57. Dissecting Epileptic and Cognitive Network Dysfunction in Epilepsy
    Pierre-Pascal Lenck-Santini and Greg Holmes
    58. Attention Deficit Disorders and Epilepsy
    Atul Maheshwari
    59. What Rodent Models Teach Us About the Association of Autism and Epilepsy
    Peyman Golshani
    60. Artificial Intelligence-Guided Behavioral Phenotyping in Epilepsy
    Tilo Gschwind and Ivan Soltesz
    61. Mechanisms of Depression in the Epileptic Brain
    Nigel Jones and Jamie Maguire
    62. Heterogeneous Mechanisms of Spreading Depolarization and Seizures
    Isamu Aiba
    63. Genetic and Cellular Mechanisms Underlying SUDEP Risk
    Jeffrey Noebels
    SECTION 8- EPILEPSY THERAPEUTICS
    Editor: Michael Rogawski; Associate Editors: Wolfgang Löscher & Steve White
    Introduction
    Michael Rogawski
    64. New Models for Assessment of Antiseizure Activity
    Cameron Metcalf, Peter West, Sharon Edwards, and Karen Wilcox
    65. Disease Biology Factors Accounting for Epilepsy Severity: An Updated Conceptual Framework for New Drug Discovery
    Stefanie Dedeurwaerdere, Vincenzo Marra, and Michael R Johnson
    66. Animal Models of Pharmacoresistant Epilepsy
    Michelle Guignet and H. Steve White
    67. Drug Combinations for Antiepileptogenesis
    Wolfgang Löscher
    68. Prophylaxis of Epileptogenesis in Injury and Genetic Epilepsy Models
    David Prince and Feng Gu
    69. Management of Febrile Status Epilepticus: Past, Present and Future
    Megan M. Garcia-Curran and Tallie Z. Baram
    70. Excitatory Transmission in Status Epilepticus
    Suchitra Joshi and Jaideep Kapur
    71. Ionic Mechanisms of Ictogenic Disinhibition: All GABA Signaling is Local
    Kevin Staley
    72. Epileptogenic Channelopathies Guide Design of NBI-921352, a Highly Isoform-Selective Inhibitor of NaV1.6
    J.P. Johnson, Jr, Alison J Cutts, James R. Empfield, and Charles J. Cohen
    73. Purinergic Signaling in Epilepsy
    Tobias Engel and Nicholas Dale
    74. Anti-Inflammatory Strategies for Disease Modification: Focus on Therapies Close to Clinical Translation
    Annamaria Vezzani, Silvia Balosso, Nicholas H. Varvel, and Ray Dingledine
    75. Targeted Augmentation of Nuclear Gene Output (TANGO)
    Lori Isom and Kelly G. Knupp
    76. Gene Therapy for Epilepsy
    Kimberly Goodspeed, Dallas Armstrong, Andrea Boitnott, Alison Dolce, Qinglan Ling, and Steve Gray
    77. Gene Therapy for Refractory Epilepsy
    Dimitri Kullmann
    78. Cell Therapy for Treatment of Epilepsy
    Sonja Bröer and Daniel Vogt
    79. Mechanisms of Ketogenic Diet Action
    Robin Williams, Detlev Boison, Susan Masino, and Jong Rho

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