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Dementia with Lewy Bodies: Clinical, Pathological, and Treatment Issues

Dementia with Lewy Bodies: Clinical, Pathological, and Treatment Issues

9780521561884
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Description
Dementia with Lewy bodies (DLB) is perhaps the second most common cause of degenerative dementia after Alzheimers disease. This book, which represents the first authoritative statement about DLB, arises from a workshop held in Newcastle, England, in October 1995, which brought together leading investigators with clinical and research experience of this condition. It includes review articles, case studies and recent research findings from the main centres studying DLB. Covering the classification, cognitive manifestations, clinical diagnosis, epidemiology, genetics, neuropathology, neurochemistry and treatment of DLB, this is a landmark publication in clinical neuroscience. It presents new operational criteria for research on DLB, and will interest all concerned with the problem of dementia in the elderly.
Product Details
Cambridge University Press
97462
9780521561884
9780521561884

Data sheet

Publication date
1996
Issue number
1
Cover
hard cover
Pages count
541
Dimensions (mm)
158.00 x 235.00
Weight (g)
905
  • 1. Introduction; Part I. Clinical Issues:: 2. The clinical diagnosis and misdiagnosis of Lewy body dementia; 3. The nosological status of Lewy body dementia; 4. Putative clinical and genetic antecedents of dementia associated with Parkinsons disease; 5. Clinical features of patients with Alzheimers disease and Lewy bodies; 6. The nature of the cognitive decline in Lewy body dementia; 7. Non-cognitive symptoms in Lewy body dementia; 8. Hallucinations, cortical Lewy body pathology, cognitive function and neuroleptic use in dementia; 9. Neuropsychological aspects of Lewy body dementia; 10. The neuroanatomical basis of cognitive deficits in Lewy body dementia; 11. The clinical and functional imaging characteristics of Parkinsonian-dementia; 12. Positron emission tomography findings in Parkinsons disease and Lewy body dementia; 13. Clinical features of diffuse Lewy body disease in the elderly:: analysis of 12 cases; 14. Senile dementia of Lewy body type - clinical features and prevalence in neuropathological postmortems; 15. Lewy body dementia in clinical practice; resume of clinical workshop sessions; Part II. Pathological Issues:: 16. Pathological significance of Lewy bodies in dementia; 17. Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies; 18. What is the neuropathological basis of dementia associated with Lewy bodies?; 19. Cytoskeletal and Alzheimer-type pathology in Lewy body disease; 20. Diffuse Lewy body disease within the spectrum of Lewy body disease; 21. Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinsons disease and senile dementia of Alzheimer type; 22. Pathological and clinical features of Parkinsons disease with and without dementia; 23. Dementia with Lewy bodies:: relationship to Parkinsons and Alzheimers diseases; 24. What do Lewy bodies tell us about dementia and Parkinsonism?; 25. Pathogenesis of the Lewy body; 26. Altered tau processing:: its role in development of dementia in Alzheimers disease and Lewy body disease; 27. Cytoskeletal pathology in Alzheimers disease and Lewy body dementia - an epiphenomenon?; 28. Genetic correlations in Lewy body disease; resume of pathological workshop sessions; Part III. Treatment Issues:: 29. Psychopharmacology of cognitive impairment in Parkinsons disease; 30. Management of the non-cognitive symptoms of Lewy body dementia; 31. Altered consciousness and transmitter signalling in Lewy body dementia; 32. Cholinergic therapy and Lewy body dementia; 33. Clinical heterogeneity in dementia; responders to cholinergic therapy; 34. Tacrine and symptomatic treatment in Lewy body dementia; 35. Neurochemical correlates of pathological and iatrogenic extrapyramidal symptoms; 36. Neurotrophins and the cholinergic system in dementia; 37. Relevance of Lewy bodies to alterations in oxidative stress in Lewy body dementia and Parkinsons disease; Resume of treatment workshop Sessions; Appendix.
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