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Huntington's Disease

Huntington's Disease

9780199929146
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Description
This fourth edition of Huntingtons Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002. Completely updated and expanded, chapters in this volume are organized in five sections:: · Clinical aspects of Huntingtons disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntingtons and the premanifest and early stages · The genetics of Huntingtons disease, including new information on its epidemiology discussions of new testing guidelines· Neurobiology, including recent insights into correlations between pathology and symptoms and a new chapter on neuronal circuitry· The molecular biology of Huntingtons disease, including new chapters on the normal function of huntingtin, the molecular pathogenesis of Huntingtons disease and the peripheral pathology of the disorder, and an extensively updated chapter on its structural biology· An updated description of the comprehensive care for Huntingtons disease, featureing a new chapter on preclinical therapeutics and a completely rewritten chapter on the state of the art of experimental therapeutics and clinical trials.
Product Details
OUP USA
84132
9780199929146
9780199929146

Data sheet

Publication date
2014
Issue number
1
Cover
hard cover
Pages count
512
Dimensions (mm)
178 x 254
Weight (g)
1041
  • Table of Contents; Section 1: Clinical aspects of Huntingtons disease; 1. Huntingtons Disease in a Historical Context; Peter S Harper; 2. Clinical Neurology of Huntingtons disease; Raymund AC Roos; 3. Neuropsychiatry and Neuropsychology; David Craufurd and Julie Snowden; 4. Juvenile Huntingtons disease; Oliver W J Quarrell; 5. Premanifest and Early Huntingtons Disease; Edward J Wild and Sarah J Tabrizi; Section 2: The genetics of Huntingtons disease; 6. Huntingtons disease: genetic and molecular studies; Cecile Cazeneuve and Alexandra Durr; 7. The Epidemiology of Huntingtons Disease; Chris Kay, Emily Fisher, Michael R. Hayden; 8. Genetic Counselling and Testing; Rhona MacLeod and Aad Tibben; Section 3: Neurobiology; 9. The Neuropathology of Huntingtons Disease in the Human Brain; Henry J Waldvogel, Eric H Kim, Lynette J Tippett, Jean-Paul G Vonsattel, and Richard LM Faull; 10. Altered Neuronal Circuitry in Huntingtons Disease; Michael S. Levine, Elizabeth A. Wang, Jane Y. Chen, Carlos Cepeda, and Veronique M. Andre; Section 4: The molecular biology of Huntingtons disease; 11. The normal function of huntingtin; Chiara Zuccato and Elena Cattaneo; 12. Order, disorder, and conformational flux in the structural biology of Huntingtons Disease; Ronald Wetzel and Rakesh Mishra; 13. Pathogenic mechanisms in Huntingtons disease; Alis Hughes and Lesley Jones; 14. Peripheral pathology in Huntingtons disease; Authors: Jorien M.M. van der Burg, N. Ahmad Aziz, Maria Björkqvist; Section 5: Therapeutic interventions in Huntingtons disease; 15. Comprehensive care in Huntingtons disease; Martha A. Nance; 16. Preclinical Experimental Therapeutics in Huntingtons Disease; Gillian P. Bates and Christian Landles; 17. Experimental Therapeutics in Huntingtons Disease: Moving Forward in Clinical Trials; Beth Borowsky and Cristina Sampaio;
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