This book aims at providing an overview and in depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that went through peer-review process. Stem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells hold a great deal of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases. These include Alzheimers and Parkinsons diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Therefore, Stem cell research is as important for the understanding of the physio- and pathology of the body, as well as for the development and therapy, including the nervous system. Volume IV provides an overview and in depth analysis of recent developments on the role and functions of newly generated neuronal cells of the adult brain in the physio- and pathology of the nervous system. It further emphasises the tremendous potential of adult neural stem cells, as a promising model, for cellular therapy and regenerative medicine.
Introduction:: Adult neurogenesis in mammals; Adult neural stem cells:: redefining the physio- and pathology of the CNS; Alzheimers disease, aneuploidy and neurogenesis; Adult neurogenesis and the pathogenesis of Alzheimers disease; Adult neurogenesis, neural stem cells and Alzheimers disease:: developments, limitations, problems and promises; Neurogenic factors are target in depression; Adult neurogenesis pharmacology in neurological diseases and disorders; Adult neurogenesis and drug therapy; Adult neural stem cells:: a promising candidate for regenerative therapy in the CNS; Adult neurogenesis, neuroinflammation and therapeutic potential of adult neural stem cells; Potential of neural stem cells for the treatment of brain tumors; Conclusion & Perspectives. Adult neural stem cells from promise to treatment:: the road ahead; Index.
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