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Molecular Mechanism and Epochal Therapeutics of Ischemic Stroke and Dementia

Invited Papers from the International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia, Okayama, Japan 18-20 October 2002, ICS 1252

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Description
This volume contains the papers presented at The International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke Dementia. Recent discoveries of the mechanism of ischemic neuronal death and Alzheimers disease have made strong impact on the work being done by neuroscientists and clinicians in this area. This volume will definitely help in the progress of future basic and clinical investigations, to encourage strong scientific collaboration in elucidating the molecular mechanism and establish the epochal therapeutics of the diseases.
Product Details
Churchill Livingstone
47912
9780444512222
9780444512222

Data sheet

Publication date
2003
Issue number
1
Cover
hard cover
Pages count
520
Weight (g)
1043
  • Preface.

    Acknowledgements.

    Role of intracellular signalling in cerebral ischemia.

    Expression of PTEN and its phosphorylated form after transient middle cerebral artery occlusion in rat (N. Omori et al.). CRE-mediated gene expression in cerebral ischemia (K. Kitagawa et al.). Poly (ADP-ribose) polymerase and brain ischemia (R.J. Traystman et al.). Effect of angiotensin II on cerebral edema following cerebral ischemia and reperfusion (N. Hosomi, T. Takahashi, M. Kohno).

    Genes and genetic models of cerebral ischemia.

    High-density DNA microarray analysis of gene expression following transient focal cerebral ischemia in mouse (S.T. Hou et al.). Hypoxic induction of vascular endothelial growth factor is impaired in the spinal cord of the mice with mutant human SOD1 gene (I. Nagano et al.). Early decrease of survival signal protein and DNA repair enzyme in spinal motor neuron of presymptomatic transgenic mice with a mutant SODl gene (M. Shiote et al.). Alteration in survival signals induction by transient hypoxia in mice expressing mutant human SODl protein (H. Ilieva et al.) Renin-angiotensin system gene polymorphism in Japanese stroke patients (T. Mizuno et al.).

    Neuroprotection with hypothermia and against inflammation.

    Mild hypothermia enhances efficacy of neuroprotective agents in cerebral ischemia in rats (T. Kamiya, Y. Katayama). Effects of aging on hypothermic neuroprotection in acute stroke (H. Naritomi et al.). The effects of a free radical scavenger, edaravone, combined with mild hypothermia on ischemic brain damage following transient middle cerebral artery occlusion in rats (C. Nito et al.). Immunophilin ameliorates apoptotic neuronal cell death (K. Tanaka, N. Ogawa). Expression of FKBPl2 after brain ischemia (H. Kato). Effects of FK506 on chronic cerebral hypoperfusion-induced discrimination leraning disabilities in Wistar rats (K. Tanaka, M. Nomura, N. Ogawa). FK506 facilitates the normalization of post-ischemic perfusion of protein kinases and tyrosine phosphorylation in the gerbil hippocampal CA1 sectors (K.-I. Katsura et al.). Nuclear factor-kappa B decoy protect spinal cord injury following ischemia/reperfusion in rats (M. Nishio et al.). Functional modulation of astrocytes by a novel agent ONO-2506 mitigates delayed infarct expansion with a wide therapeutic time window, inducing prompt neurological recovery through reduction of the extracellular level of glutamate (T. Asano et al.).

    Molecular mechanisms and therapy for ischemic brain damage.

    Caspases and upstream mechanisms in central nervous system ischemic injury (M.A. Moskowitz, D.A. Le, M.J. Whalen). Spatiotemporal changes of free cholesterol and neutral lipids after transient focal cerebral ischemia in rats (H. Kamada et al.). Apolipoprotein E influences neuronal death and repair (K. Horsburgh et al.). Suppression of protein synthesis after transient cerebral ischemia (W. Paschen, T. Mengesdorf, C. Aufenberg). New vessel formation and expression of angiogenesis-related genes in brain after ischemia (T. Hayashi, P.H. Chan). Therapeutic time window of rt-PA on embolic stroke in rat (S. Okubo et al). Expression of LOX-I in spontaneously hypertensive rat carotid atherosclerotic lesions (Y. Hamakawa et al.). Expression of p-TEN and C signals in rat brain neurons after transient MCAO (F. Li et al.). Protection against ischemic brain damage by GDNF affecting cell survival and death signals (G. Jin et al.).

    Neurotrophic factors and gene therapy for stroke.

    Neuroprotection by drug-induced growth factors (Y. Zhu, J. Krieglstein). Neurotrophic factor delivery by encapsulated cell grafts (I. Date, T. Shingo, T. Ohmoto). Gene therapy for cerebral arteries (H. Ooboshi, S. Ibayashi). Therapeutic time window of glial cell line-derived neurotrophic factor after transient middle cerebral artery occlusion in rat (W.A. Zhang et al.). Therapeutic time window of Ad-GDNF after transient middle cerebral artery occlusion in rat (W.A. Zhang et al.). Attenuation of neuronal cell death by SODl is associated with extracellular signal-regulated kinase after transient focal cerebral ischemia in mice (N. Noshita et al.). Adenovirus-mediated gene transfer to ischemic brain (J. Takada et al.). The change of distribution and mRNA expression of brain-derived neurotrophic factor after intrastriatal hemorrhage (Y. Kanda et al.).

    Imaging of brain function.

    Assessment of neuroreceptor changes in healthy ageing and in Alzheimers disease with emission tomography (G. M. Knudsen). MR imaging in acute stroke (K. Minematsu). New MEG technology for evaluating focal brain function (T. Yoshimine et al.). Imaging of remote areas after focal cerebral ischemia (A. Tamura et al.). Propagation of recurrent depolarization in the penumbra in the rat - use of in vivo cortical NADH fluorescence - (Y. Takeda, T. Higuchi, K. Morita). Quantitative aspects of neurovascular interaction (I. Kanno). Predicting the pathological fate of focal cerebral ischemia usinglH-magnetic resonance spectroscopic imaging (H. Igarashi et al.).

    Molecular mechanism of Alzheimers disease and the therapeutic potentials.

    Distinct functions or tau isoforms in Alzheimers disease (H. Mori et al.). ă-Cleavage and ĺ-cleavage of â-amyloid precursor protein (M. Morishima-Kawashima, Y. Ihara). COX-2 expression in brains of patients with familial Alzheimers disease (S. Nogawa et al.). Accumulation of amyloid â protein in Tg2576 mice (T. Kawarabayashi et al.). Molecular pathology of transgenic tau mice (T. Murakami et al.). Heat shock proteins reduce aggregation and facilitate degradation of tau protein (F.Dou et al.). Alzheimers disease and melatonin (E. Matsubara et al.). Aâ42 vaccine on the Tg2576 Alzheimer model mice (M. Shoji et al.). Aâ vaccination of a genetic model of Alzheimers disease (H. Hasegawa et al.). Somatosensory-evoked fields in Alzheimers disease (K. Inoue et al.).

    Activation of stem cell in ischemic brain.

    Highly polysialylated neural cell adhesion molecule positive cells increased and changed localization in rat hippocampus with exposure to repeated kindled seizures (K. Sato et al.). Activation of neural stem cells after global brain ischemia (M. Iwai et al.). Activation and proliferation of oligodendrocyte progenitor cells after brain ischemia in the rat (K. Tanaka et al.). Cyclooxygernse-2 is involved in increased proliferation of neurornal progenitor cells in the ischemic mouse hippocampus (T. Sasaki et al.). Comparison of proliferation of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia (K. Ohta et al.).

    Stem cell therapy for ischemic brain.

    Differentiation of bone marrow cells in culture and in vivo (H. Miyazaki et al.). Treatment of stroke with marrow stromal cells (M. Chopp, Y. Li). Transplantation of mesenchymal stem cells derived from the bone marrow into the demyelinated spinal cord (A. Bizen et al.). Transplantation of neural stem cells into ischemic brain (O. Honmou). Cell therapy for cerebral ischemia using vascular endothelial growth factor-secreting cells (T. Shingo et al.). Transplantation of neural stem cells into epileptic brain (Y. Matsumoto et al.). Neural stem cells as therapeutic agents for CNS injuries and disorders (H. Okano).

    Author index.

    Keyword index.
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