This issue examines what is a healthy aging brain and covers preventive measures for succesful cognitive aging. Topics covered include:: A road map to healthy aging brain; Cardiovascular risk factors, cerebrovascular disease burden and healthy aging brain; Healthy aging brain:: Impact of head injury, alcohol and environmental toxins; Healthy aging brain:: What has sleep go to do with it?; Endocrine aspects of healthy aging brain; Healthy aging brain:: Role of exercise and physically active lifestyle; Healthy aging brain:: Role of nutrition and nutritional supplements; Healthy aging brain:: Role of cognitive reserve, cognitive stimulation and cognitive exercises; Healthy aging brain:: Impact of positive and negative emotions; Dementia risk predictor. Are we there yet?; Potential future neuroprotective therapies for neurodegenerative disorders and stroke; Healthy aging brain:: Importance of promoting resilience and creativity.