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Multiple Sclerosis and Demyelinating Diseases

9780781751704
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Description

This volume in the distinguished Advances in Neurology series focuses on multiple sclerosis and related demyelinating diseases. An international group of experts examines recent developments in diagnosis, treatment, and other aspects of clinical management. The latest cutting-edge research on the causes and mechanisms of these diseases is also discussed.

Coverage includes detailed discussions on new diagnostic methods and the role of neuroimaging in diagnosis. Chapters present evidence-based treatment protocols and review current clinical testing of new therapies.

Product Details
Lippincott Williams & Wilkins
38977
9780781751704
9780781751704

Data sheet

Publication date
2005
Issue number
1
Cover
hard cover
Pages count
512
Dimensions (mm)
178 x 254
Weight (g)
853
    1. Multiple Sclerosis
      1. Natural history::
        1. The London, Ontario database
        2. The Lyon database
        Genetic Aspects Pathology::
        1. Heterogeneity of pathology
        2. Gray vs. White matter disease-Proposed author:: Bruce Trapp. 30 manuscript pages including tables and references; 5 photos/diagrams
        Biology of MS::
        This section will discuss the current knowledge regarding the function of oligodendrocytes, their derivision from precursor cells, their properties (mostly from in vitro studies) and the potential for regeneration. Additionally, some studies are examining the genes that govern their differentiation, growth and function, .
        1. The Biology of Oligodendrocytes-Proposed author:: Jack Antel. 30 manuscript pages including tables and references; 3 photos/diagrams
        2. Molecular Aspects of Oligodendrocytes-Proposed author:: Alan Peterson. 30 manuscript pages including tables and references; 3 photos/diagrams
        Pathophysiology This section will examine the contributions from animal models that has led to proven concepts in the human disease and some of the proposed autoimmune mechanisms believed to play a role and are amenable to treatment.
        1. Animal models-Proposed author:: Moses Rodriguez. 30 manuscript pages including tables and references; 4 photos/diagrams
        2. Human Immune Studies-Proposed author:: Amit Bar-Or. 30 manuscript pages including tables and references; 4 photos/diagrams
        Diagnosis and Differential Diagnosis There are now accepted criteria that involve clinical, MRI and cerebrospinal fluid (CSF) analysis to define ‘definite’ vs. ‘possible’ MS. The section on MS Mimics will address the number of conditions that could look like MS and even fulfill the criteria but need to therefore be differentiated.
        1. The Clinical Diagnosis of MS-Proposed author:: Ian MacDonald and Alan Thompson. 40 manuscript pages including tables and references; 5 photos/diagrams
        2. The Role of MRI in the Diagnosis of MS-Proposed authors:: Tony Traboulsee and Don Paty. 40 manuscript pages including tables and references; 5 photos/diagrams
        3. The Role of CSF-Proposed authors:: Ed Thompson and Mark Freedman. 40 manuscript pages including tables and references; 5 photos/diagrams
        4. MS Mimics-Proposed author:: Patricia Coyle. 40 manuscript pages including tables and references; 5 photos/diagrams
        The Role of MRI
        A separate volume alone could be devoted to this topic, so the salient features only will be sought from the almost two decades of research put into this area. Newer areas in development that allow for better visualization of myelin vs. axonal elements, gray matter disease and atrophy will all be addressed.
        1. The Natural History of MS MRI-Proposed author:: David Miller. 20 manuscript pages including tables and references; 8 photos/diagrams
        2. Cranial MRI-Proposed author:: Massimo Fillippi and Giancarlo Comi. 20 manuscript pages including tables and references; 8 photos/diagrams
        3. Spinal cord MRI-Proposed author:: Fred Barkhof and Geert Lycklama. 20 manuscript pages including tables and references; 8 photos/diagrams
        4. MR Spectroscopy and fMRI-Proposed author:: Douglas Arnold. 20 manuscript pages including tables and references; 8 photos/diagrams
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