The two volumes on Parkinsons disease in the Handbook of Clinical Neurology (Series Editors:: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; François Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) cover a group of disorders that constitute the commonest of neurodegenerative diseases and one that is assuming ever greater importance with the ageing of the population in developed countries. The coverage reflects the dramatic advances in understanding of the biochemical background of parkinsonism and the resulting developments in the pharmacological management of the disease. These volumes give a comprehensive account of the subject for both clinical neurologists and those researching in the neurosciences.
Part I covers the scientific background, general aspects of Parkinsons disease, clinical aspects and etiology. Part II covers the medical and surgical treatment of Parkinsons disease, complications of therapy and the other parkinsonian syndromes.
Section 5: Treatment of Parkinsons disease Physical therapy in Parkinsons disease. Neuroprotection in Parkinsons disease: clinical trials. Levodopa. Dopamine agonists. Monoamine oxidase A and B inhibitors in Parkinsons disease. Anticholinergic medications. Antiglutamatergic drugs in the treatment of Parkinsons disease. Investigational drugs. The importance of patients groups and collaboration Section 6: Complications of therapy Motor and non-motor fluctuations. Levodopa-induced dyskinesias in Parkinsons disease. Treatment induced mental changes in Parkinsons disease. Section 7 Surgical treatment Ablative surgery for the treatment of Parkinsons disease. Deep brain stimulation. Transplantation. Gene therapy approaches for the treatment of Parkinsons disease. Section 8: Other parkinsonian disease syndromes Multiple system atrophy. Progressive supranuclear palsy. Corticobasal degeneration. Infectious basis to the pathogenesis of Parkinsons disease. Toxic causes of Parkinsons disease. Drug induced parkinsonism. Vascular parkinsonism. Old age and Parkinsons disease. Other degenerative processes. Hydrocephalus and structural lesions. Calcification of the basal ganglia. Trauma and Parkinsons disease. Psychogenic parkinsonism. Parkinsonism and dystonia. Dementia with Lewy bodies. Myoclonus and parkinsonism.
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