This volume in the Handbook of Clinical Neurology (Series Editors:: Michael J. Aminoff, Department of Neurology, University of California, San Francisco, USA; François Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) on motor neuron disorders and related diseases deals with the remarkable advances that have occured in recent years in the understanding of these disorders and their underlying molecular pathogenesis. An account is also provided of the general clinical features and mangement of these devasting disorders, which will be invaluable to all those who care for patients affected by them.
1. Historical aspects of motor neuron diseases, Andrew A. Eisen (Vancouver, Canada)
SECTION 1 Basic aspects
2. Comparative anatomy and physiology of the corticospinal system, Marc H. Schieber (Rochester, NY, USA)
3. Development of the corticospinal system and spinal motor circuits, John H. Martin (New York, NY, USA)
4. Molecular mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis, Siân C. Barber and Pamela J. Shaw (Sheffield, UK)
5. Cytopathology of the motor neuron, Paul G. Ince and Stephen B. Wharton (Sheffield, UK)
6. Animal models of motor neuron death, Jean-Pierre Julien and Jasna Kriz (Quebec, Canada)
SECTION 2 Anterior horn cell disorders and motor neuropathies
7. Spinal muscular atrophies and hereditary motor neuropathies, Kevin Talbot and Kay E. Davies (Oxford, UK)
8. Spinobulbar muscular atrophy (Kennedys disease), Jean-Marc Gallo and P. Nigel Leigh (London, UK)
9. GM2 gangliosidoses, Amos D. Korczyn (Ramat-Aviv, Israel)
10. Viral infections of lower motor neurons, Tom Solomon, Mong How Ooi and Macpherson Mallewa (Liverpool, UK and Sarawak, Malaysia)
11. Monomelic amyotrophy of upper or lower limbs, M. Gourie-Devi (New Delhi, India)
12. Multifocal and other motor neuropathies, Leonard H. van den Berg, Hessel Franssen, Jan-Thies H. van Asseldonk, Renske M. van den Berg-Vos and John H. J. Wokke (Utrecht, The Netherlands)
SECTION 3 Amyotrophic lateral sclerosis
13. Amyotrophic lateral sclerosis, P. Nigel Leigh (London, UK)
14. Familial amyotrophic lateral sclerosis, Christopher E. Shaw, Virginia Arechavala-Gomeza and Ammar Al-Chalabi (London, UK)
15. Juvenile amyotrophic lateral sclerosis, Paul Orban, Rebecca S. Devon, Michael R. Hayden and Blair R. Leavitt (Vancouver, Canada and Edinburgh, UK)
SECTION 4 Corticospinal disorders
16. Primary lateral sclerosis, Andrew A. Eisen (Vancouver, Canada)
17. Hereditary spastic paraparesis, Christopher J. McDermott and Pamela J. Shaw (Sheffield, UK)
18. Toxic disorders of the upper motor neuron system, D. Desire Tshala-Katumbay and Peter S. Spencer (Portland, OR, USA)
SECTION 5 Therapeutic aspects
19. Therapies in amyotrophic lateral sclerosis: options for the near and far future, Robin Lemmens, Ludo Van Den Bosch and Wim Robberecht (Leuven, Belgium)
20. Symptomatic therapy and palliative aspects of clinical care, Paul H. Gordon and Hiroshi Mitsumoto (New York, NY, USA)
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