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Jawetz Melnick & Adelbergs Medical Microbiology 28e (IE)

Jawetz Melnick & Adelbergs Medical Microbiology 28e (IE)

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9781260460247
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Description



Understand the clinically relevant aspects of microbiology with this student-acclaimed, full-color review --- bolstered by case studies and hundreds of USMLE®-style review questions


Since 1954, Jawetz, Melnick & Adelbergs Medical Microbiology has been hailed by students, instructors, and clinicians as the single-best resource for understanding the roles microorganisms play in human health and illness. 

Concise and fully up to date, this trusted classic links fundamental principles with the diagnosis and treatment of microbial infections. Along with brief descriptions of each organism, you will find vital perspectives on pathogenesis, diagnostic laboratory tests, clinical findings, treatment, and epidemiology. The book also includes an entire chapter of case studies that focuses on differential diagnosis and management of microbial infections.

Heres why Jawetz, Melnick & Adelbergs Medical Microbiology is essential for USMLE® review:: 

•640+ USMLE-style review questions 
•350+ illustrations 
•140+ tables
•22 case studies to sharpen your differential diagnosis and management skills 
•An easy-to-access list of medically important microorganisms 
•Coverage that reflects the latest techniques in laboratory and diagnostic technologies 
•Full-color images and micrographs 
•Chapter-ending summaries 
•Chapter concept checks

Jawetz, Melnick & Adelbergs Medical Microbiology, Twenty-Eighth Edition effectively introduces you to basic clinical microbiology through the fields of bacteriology, mycology, and parasitology, giving you a thorough yet understandable review of the discipline. Begin your review with it and see why there is nothing as time tested or effective. 

Product Details
McGraw Hill / Medical
93912
9781260460247
9781260460247

Data sheet

Publication date
2019
Issue number
28
Cover
paperback
Pages count
880
Dimensions (mm)
213 x 274
Weight (g)
1760
  • Preface
    Section I Fundamentals of Microbiology
    1. The Science of Microbiology
    Introduction
    Biologic Principles Illustrated by Microbiology
    Viruses
    Prions
    Prokaryotes
    Protists
    Chapter Summary
    Review Questions
    2. Cell Structure
    Optical Methods
    Eukaryotic Cell Structure
    Prokaryotic Cell Structure
    Staining
    Morphologic Changes During Growth
    Chapter Summary
    Review Questions
    3. Classification of Bacteria
    Taxonomy—The Vocabulary of Medical Microbiology
    Criteria for Identification of Bacteria
    Classification Systems
    Description of the Major Categories and Groups of Bacteria
    Nonculture Methods for the Identification of Pathogenic Microorganisms
    Updates to Taxonomic Changes
    Objectives
    Review Questions
    4. Growth, Survival, and Death of Microorganisms
    Survival of Microorganisms in the Natural Environment
    The Meaning of Growth
    Exponential Growth
    The Growth Curve in Batch Culture
    Maintenance of Cells in the Exponential Phase
    Growth in Biofilms
    Definition and Measurement of Death
    Environmental Control of Microbial Growth
    Strategies to Control Bacteria at the Environmental Level
    General Mechanisms of Biocide Action
    Specific Actions of Selected Biocides
    Relationship of Biocide Concentration and Time on Antimicrobial Killing
    Summary
    Key Concepts
    Review Questions
    5. Cultivation of Microorganisms
    Requirements for Growth
    Sources of Metabolic Energy
    Nutrition
    Environmental Factors Affecting Growth
    Cultivation Methods
    Chapter Summary
    Review Questions
    6. Microbial Metabolism
    Role of Metabolism in Biosynthesis and Growth
    Focal Metabolites and Their Interconversion
    Assimilatory Pathways
    Biosynthetic Pathways
    Patterns of Microbial Energy-Yielding Metabolism
    Regulation of Metabolic Pathways
    Chapter Summary
    Review Questions
    7. Microbial Genetics
    Nucleic Acids and Their Organization in Eukaryotic, Prokaryotic, and Viral Genomes
    Replication
    Transfer of DNA
    Mutation and Gene Rearrangement
    Gene Expression
    Genetic Engineering
    Characterization of Cloned DNA
    Site-Directed Mutagenesis
    Analysis of DNA, RNA, or Protein-Expressing Clones
    Manipulation of Cloned DNA
    Chapter Summary
    Review Questions
    Section II Immunology
    8. Immunology
    Overview
    Innate Immunity
    Adaptive Immunity
    Complement
    Cytokines
    Microbiome and Immune System
    Hypersensitivity
    Defects of the Immune Response
    Tumor Immunology
    Clinical Immunology Laboratory (Diagnostic Testing)
    Chapter Summary
    Review Questions
    Section III Bacteriology
    9. Pathogenesis of Bacterial Infection
    Identifying Bacteria That Cause Disease
    Transmission of Infection
    The Infectious Process
    Genomics and Bacterial Pathogenicity
    Regulation of Bacterial Virulence Factors
    Bacterial Virulence Factors
    The Damage-Response Framework—A New Paradigm of Microbial Virulence and Pathogenicity
    Chapter Summary
    Review Questions
    10. Normal Human Microbiota
    Human Microbiome Project
    Role of the Resident Microbiota
    Normal Microbiota of the Skin
    Normal Microbiota of the Mouth and Upper Respiratory Tract
    Normal Microbiota of the Urethra
    Normal Microbiota of the Vagina
    Normal Microbiota of the Placenta and Uterus
    Normal Microbiota of the Conjunctiva
    Chapter Summary
    Review Questions
    11. Spore-Forming Gram-Positive Bacilli: Bacillus and Clostridium Species
    Bacillus species
    Bacillus anthracis
    Bacillus cereus
    Clostridium species
    Clostridium botulinum
    Clostridium tetani
    Clostridia That Produce Invasive Infections
    Clostridium difficile and Diarrheal Disease
    Review Questions
    12. Aerobic Non–Spore-Forming Gram-Positive Bacilli: Corynebacterium, Listeria, Erysipelothrix, Nocardia, and Related Pathogens
    Corynebacterium diphtheriae
    Other Coryneform Bacteria
    Listeria monocytogenes
    Erysipelothrix rhusiopathiae
    Rhodococcus equi
    Nocardiosis
    Review Questions
    13. The Staphylococci
    Chapter Summary
    Review Questions
    14. The Streptococci, Enterococci, and Related Genera
    Classification of Streptococci
    Streptococci, Enterococci, and Related Genera of Particular Medical Interest
    Streptococcus pyogenes
    Streptococcus agalactiae
    Groups C and G
    Group D Streptococci
    Streptococcus anginosus Group
    Groups E, F, G, H, and K–U Streptococci
    Viridans Streptococci
    Nutritionally Variant Streptococci
    Peptostreptococcus and Related Genera
    Streptococcus pneumoniae
    Enterococci
    Other Catalase-Negative Gram-Positive Cocci
    Review Questions
    15. Enteric Gram-Negative Rods (Enterobacteriaceae)
    Classification
    Diseases Caused by Enterobacteriaceae Other Than Salmonella and Shigella
    The Shigellae
    The Salmonellae
    Chapter Summary
    Review Questions
    16. Pseudomonas, Acinetobacter, Burkholderia, and Stenotrophomonas
    The Pseudomonad Group
    Pseudomonas aeruginosa
    Burkholderia pseudomallei and Burkholderia mallei
    Burkholderia cepacia Complex
    Stenotrophomonas maltophilia
    Acinetobacter
    Chapter Summary
    Review Questions
    17. Vibrio, Aeromonas, Campylobacter, and Helicobacter
    The Vibrios
    Vibrio cholerae
    Vibrio parahaemolyticus and Vibrio vulnificus
    Aeromonas species
    Campylobacter
    Campylobacter jejuni
    Helicobacter pylori
    Chapter Summary
    Review Questions
    18. Haemophilus, Bordetella, Brucella, and Francisella
    The Haemophilus species
    Haemophilus influenzae
    Haemophilus aegypticus
    Aggregatibacter aphrophilus
    Haemophilus ducreyi
    Other Haemophilus Species
    The Bordetellae
    Bordetella pertussis
    Bordetella parapertussis
    Bordetella bronchiseptica
    Francisella tularensis and Tularemia
    Review Questions
    19. Yersinia and Pasteurella
    Yersinia pestis and Plague
    Yersinia enterocolitica and Yersinia pseudotuberculosis
    Pasteurella multocida
    Chapter Summary
    Review Questions
    20. The Neisseriae
    Neisseria gonorrhoeae
    Neisseria meningitidis
    Other Neisseriae
    Chapter Summary
    Review Questions
    21. Infections Caused by Anaerobic Bacteria
    Physiology and Growth Conditions for Anaerobes
    Anaerobic Bacteria Found in Human Infections
    Bacteria That Cause Vaginosis
    Gardnerella vaginalis
    Pathogenesis of Anaerobic Infections
    The Polymicrobial Nature of Anaerobic Infections
    Diagnosis of Anaerobic Infections
    Treatment of Anaerobic Infections
    Chapter Summary
    Review Questions
    22. Legionella, Bartonella, and Unusual Bacterial Pathogens
    Legionella pneumophila and Other Legionellae
    Bartonella
    Streptobacillus moniliformis
    Whipple Disease
    Review Questions
    23. Mycobacteria
    Mycobacterium tuberculosis
    Other Mycobacterium
    Mycobacterium leprae
    Review Questions
    24. Spirochetes: Treponema, Borrelia, and Leptospira
    Treponema pallidum and Syphilis
    Borrelia
    Borrelia species and Relapsing Fever
    Borrelia burgdorferi and Lyme Disease
    Leptospira and Leptospirosis
    Chapter Summary
    Review Questions
    25. Mycoplasmas and Cell Wall–Defective Bacteria
    Mycoplasmas
    Mycoplasma pneumoniae and Atypical Pneumonias
    Mycoplasma hominis
    Ureaplasma urealyticum
    Mycoplasma genitalium
    Chapter Summary
    Review Questions
    26. Rickettsia and Related Genera
    General
    Rickettsia and Orientia
    Ehrlichia and Anaplasma
    Coxiella burnetii
    Review Questions
    27. Chlamydia spp.
    Chlamydia trachomatis Ocular, Genital, and Respiratory Infections
    Trachoma
    Chlamydia trachomatis Genital Infections and Inclusion Conjunctivitis
    Chlamydia trachomatis and Neonatal Pneumonia
    Lymphogranuloma Venereum
    Chlamydia pneumoniae and Respiratory Infections
    Chlamydia psittaci and Psittacosis
    Chapter Summary
    Review Questions
    28. Antimicrobial Chemotherapy
    Mechanisms of Action of Antimicrobial Drugs
    Selective Toxicity
    Inhibition of Cell Wall Synthesis
    Inhibition/Alteration of Cell Membrane Function
    Inhibition of Protein Synthesis
    Inhibition of Nucleic Acid Synthesis
    Resistance to Antimicrobial Drugs
    Origin of Drug Resistance
    Cross-Resistance
    Limitation of Drug Resistance
    Clinical Implications of Drug Resistance
    Antimicrobial Activity in vitro
    Factors Affecting Antimicrobial Activity
    Measurement of Antimicrobial Activity
    Antimicrobial Activity in vivo
    Drug–Pathogen Relationships
    Host–Pathogen Relationships
    Clinical Use of Antibiotics
    Selection of Antibiotics
    Dangers of Indiscriminate Use
    Antimicrobial Drugs Used in Combination
    Antimicrobial Chemoprophylaxis
    Antimicrobial Drugs For Systemic Administration
    Penicillins
    Cephalosporins
    Other ß-Lactam Drugs
    Tetracyclines
    Glycylcyclines
    Chloramphenicol
    Macrolides
    Clindamycin and Lincomycin
    Glycopeptides, Lipopeptides, Lipoglycopeptides
    Streptogramins
    Oxazolidinones
    Bacitracin
    Polymyxins
    Aminoglycosides
    Quinolones
    Sulfonamides and Trimethoprim
    Other Drugs With Specialized Uses
    Drugs Used Primarily to Treat Mycobacterial Infections
    Review Questions
    Section IV Virology
    29. General Properties of Viruses
    Terms and Definitions in Virology
    Evolutionary Origin of Viruses
    Classification of Viruses
    Principles of Virus Structure
    Chemical Composition of Viruses
    Cultivation and Detection of Viruses
    Purification and Identification of Viruses
    Laboratory Safety
    Reaction to Physical and Chemical Agents
    Replication of Viruses: An Overview
    Genetics of Animal Viruses
    Natural History (Ecology) and Modes of Transmission of Viruses
    Chapter Summary
    Review Questions
    30. Pathogenesis and Control of Viral Diseases
    Principles of Viral Diseases
    Pathogenesis of Viral Diseases
    Prevention and Treatment of Viral Infections
    Chapter Summary
    Review Questions
    31. Parvoviruses
    Properties of Parvoviruses
    Parvovirus Infections in Humans
    Chapter Summary
    Review Questions
    32. Adenoviruses
    Properties of Adenoviruses
    Adenovirus Infections in Humans
    Chapter Summary
    Review Questions
    33. Herpesviruses
    Properties of Herpesviruses
    Herpesvirus Infections in Humans
    Herpes Simplex Viruses
    Varicella-Zoster Virus
    Epstein-Barr Virus
    Cytomegalovirus
    Human Herpesvirus 6
    Human Herpesvirus 7
    Human Herpesvirus 8
    Herpes B Virus
    Chapter Summary
    Review Questions
    34. Poxviruses
    Properties of Poxviruses
    Poxvirus Infections in Humans: Vaccinia and Variola
    Monkeypox Infections
    Cowpox Infections
    Buffalopox Infections
    Orf Virus Infections
    Molluscum Contagiosum
    Tanapox and Yaba Monkey Tumor Poxvirus Infections
    Chapter Summary
    Review Questions
    35. Hepatitis Viruses
    Properties of Hepatitis Viruses
    Hepatitis Virus Infections in Humans
    Chapter Summary
    Review Questions
    36. Picornaviruses (Enterovirus and Rhinovirus Groups)
    Properties of Picornaviruses
    Enterovirus Group
    Polioviruses
    Coxsackieviruses
    Other Enteroviruses
    Enteroviruses in the Environment
    Rhinoviruses
    Parechovirus Group
    Foot-and-Mouth Disease (Aphthovirus of Cattle)
    Chapter Summary
    Review Questions
    37. Reoviruses, Rotaviruses, and Caliciviruses
    Reoviruses and Rotaviruses
    Rotaviruses
    Reoviruses
    Orbiviruses and Coltiviruses
    Caliciviruses
    Astroviruses
    Chapter Summary
    Review Questions
    38. Arthropod-Borne and Rodent-Borne Viral Diseases
    Human Arbovirus Infections
    Togavirus and Flavivirus Encephalitis
    Yellow Fever Virus
    Dengue Virus
    Bunyavirus Encephalitis Viruses
    Sandfly Fever Virus
    Rift Valley Fever Virus
    Severe Fever with Thrombocytopenia Syndrome Virus
    Heartland Virus
    Colorado Tick Fever Virus
    Rodent-Borne Hemorrhagic Fevers
    Bunyavirus Diseases
    Arenavirus Diseases
    Filovirus Diseases
    Chapter Summary
    Review Questions
    39. Orthomyxoviruses (Influenza Viruses)
    Properties of Orthomyxoviruses
    Influenza Virus Infections in Humans
    Chapter Summary
    Review Questions
    40. Paramyxoviruses and Rubella Virus
    Properties of Paramyxoviruses
    Parainfluenza Virus Infections
    Respiratory Syncytial Virus Infections
    Human Metapneumovirus Infections
    Mumps Virus Infections
    Measles (Rubeola) Virus Infections
    Hendra Virus and Nipah Virus Infections
    Rubella (German Measles) Virus Infections
    Postnatal Rubella
    Congenital Rubella Syndrome
    Chapter Summary
    Review Questions
    41. Coronaviruses
    Properties of Coronaviruses
    Coronavirus Infections in Humans
    Chapter Summary
    Review Questions
    42. Rabies, Slow Virus Infections, and Prion Diseases
    Rabies
    Borna Disease
    Slow Virus Infections and Prion Diseases
    Chapter Summary
    Review Questions
    43. Human Cancer Viruses
    General Features of Viral Carcinogenesis
    Molecular Mechanisms of Carcinogenesis
    Interactions of Tumor Viruses with Their Hosts
    RNA Tumor Viruses
    Hepatitis C Virus
    Retroviruses
    DNA Tumor Viruses
    Hepatitis B Virus
    Polyomaviruses
    Papillomaviruses
    Adenoviruses
    Herpesviruses
    Poxviruses
    How to Prove That a Virus Causes Human Cancer
    Chapter Summary
    Review Questions
    44. AIDS and Lentiviruses
    Properties of Lentiviruses
    HIV Infections in Humans
    Chapter Summary
    Review Questions
    Section V Mycology
    45. Medical Mycology
    General Properties, Virulence, and Classification of Pathogenic Fungi
    Laboratory Diagnosis of Mycoses
    Superficial Mycoses
    Cutaneous Mycoses
    Key Concepts: Superficial and Cutaneous Mycoses
    Subcutaneous Mycoses
    Sporotrichosis
    Chromoblastomycosis
    Phaeohyphomycosis
    Mycetoma
    Key Concepts: Subcutaneous Mycoses
    Endemic Mycoses
    Coccidioidomycosis
    Histoplasmosis
    Blastomycosis
    Paracoccidioidomycosis
    Key Concepts: Endemic Mycoses
    Opportunistic Mycoses
    Candidiasis
    Cryptococcosis
    Aspergillosis
    Mucormycosis
    Pneumocystis Pneumonia
    Penicilliosis
    Other Opportunistic Mycoses
    Emerging Pathogens
    Key Concepts: Opportunistic Mycoses
    Antifungal Prophylaxis
    Hypersensitivity to Fungi
    Mycotoxins
    Antifungal Chemotherapies
    Topical Antifungal Agents
    Key Concepts: Antifungal Chemotherapy
    Review Questions
    Section VI Parasitology
    46. Medical Parasitology
    Classification of Parasites
    Intestinal Protozoan Infections
    Giardia lamblia (Intestinal Flagellate)
    Entamoeba histolytica (Intestinal and Tissue Ameba)
    Other Intestinal Amebae
    Cryptosporidium (Intestinal Sporozoa)
    Cyclospora (Intestinal Sporozoa)
    Sexually Transmitted Protozoan Infection
    Trichomonas vaginalis (Genitourinary Flagellate)
    Blood and Tissue Protozoan Infections
    Blood Flagellates
    Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense (Blood Flagellates)
    Trypanosoma cruzi (Blood Flagellate)
    Leishmania Species (Blood Flagellates)
    Entamoeba histolytica (Tissue Ameba)—See Intestinal Protozoan Infections Section
    Naegleria fowleri, Acanthamoeba castellanii, and Balamuthia mandrillaris (Free-Living Amebae)
    Plasmodium Species (Blood Sporozoa)
    Babesia microti (Blood Sporozoa)
    Toxoplasma gondii (Tissue Sporozoa)
    Microsporidia
    Intestinal Helminthic Infections
    Enterobius vermicularis (Pinworm—Intestinal Nematode)
    Trichuris trichiura (Whipworm—Intestinal Nematode)
    Ascaris lumbricoides (Human Roundworm—Intestinal Nematode)
    Ancylostoma duodenale and Necator americanus (Human Hookworms—Intestinal Nematode)
    Strongyloides stercoralis (Human Threadworm—Intestinal and Tissue Nematode)
    Trichinella spiralis (Intestinal and Tissue Nematode)
    Fasciolopsis buski (Giant Intestinal Fluke—Intestinal Trematode)
    Taenia saginata (Beef Tapeworm—Intestinal Cestode) and Taenia solium (Pork Tapeworm—Intestinal and Tissue Cestode)
    Diphyllobothrium latum (Broad Fish Tapeworm—Intestinal Cestode)
    Hymenolepis nana (Dwarf Tapeworm—Intestinal Cestode)
    Dipylidium caninum (Dog Tapeworm—Intestinal Cestode)
    Blood And Tissue Helminthic Infections
    Wuchereria bancrofti, Brugia malayi, and Brugia timori (Lymphatic Filariasis—Tissue Nematodes)
    Onchocerca volvulus (River Blindness—Tissue Nematode)
    Dracunculus medinensis (Guinea Worm—Tissue Nematode)
    Larva migrans (Zoonotic Larval Nematode Infections)
    Clonorchis Sinensis (Chinese Liver Fluke), Fasciola hepatica (Sheep Liver Fluke), and Paragonimus westermani (Lung Fluke)—Tissue Trematodes
    Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium (Blood Flukes)
    Tissue Cestode Infections (Caused by the Larval Stages)
    Taenia solium—Cysticercosis/Neurocysticercosis
    Echinococcus granulosus (Hydatid Cyst)
    Review Questions
    Section VII Diagnostic Medical Microbiology and Clinical Correlation
    47. Principles of Diagnostic Medical Microbiology
    Communication Between Physician and Laboratory
    Diagnosis of Bacterial and Fungal Infections
    The Importance of Normal Bacterial and Fungal Microbiota
    Laboratory Aids in the Selection of Antimicrobial Therapy
    Diagnosis of Infection by Anatomic Site
    Anaerobic Infections
    Diagnosis of Chlamydial Infections
    Diagnosis of Viral Infections
    Review Questions
    48. Cases and Clinical Correlations
    Central Nervous System
    Respiratory
    Heart
    Abdomen
    Urinary Tract
    Bone and Soft Tissue
    Sexually Transmitted Diseases
    Mycobacterium tuberculosis Infections
    Myocobacterium Avium Complex
    Infections in Transplant Patients
    Emerging Infections
    Index
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