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Bioinformatics and Functional Genomics

Bioinformatics and Functional Genomics

9781118581780
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Description

The bestselling introduction to bioinformatics and genomics – now in its third edition

Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research.

This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include::

  • Extensive revisions and a slight reorder of chapters for a more effective organization
  • A brand new chapter on next-generation sequencing
  • An expanded companion website, also updated as and when new information becomes available
  • Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities

The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations:: www.wiley.com/go/pevsnerbioinformatics.

Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Product Details
76264
9781118581780
9781118581780

Data sheet

Publication date
2015
Issue number
3
Cover
hard cover
Pages count
1160
Dimensions (mm)
221.00 x 284.00
Weight (g)
3050
  • Part I Analyzing DNA, RNA, and Protein Sequences

    1 Introduction 3

    2 Access to Sequence Data and Related Information 19

    3 Pairwise Sequence Alignment 69

    4 Basic Local Alignment Search Tool (BLAST) 121

    5 Advanced Database Searching 167

    6 Multiple Sequence Alignment 205

    7 Molecular Phylogeny and Evolution 245

    Part II Genomewide Analysis of DNA, RNA, and Protein

    8 DNA: The Eukaryotic Chromosome 307

    9 Analysis of Next-Generation Sequence Data 377

    10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433

    11 Gene Expression: Microarray and RNA-seq Data Analysis 479

    12 Protein Analysis and Proteomics 539

    13 Protein Structure 589

    14 Functional Genomics 635

    Part III Genome Analysis

    15 Genomes Across the Tree of Life 699

    16 Completed Genomes: Viruses 755

    17 Completed Genomes: Bacteria and Archaea 797

    18 Eukaryotic Genomes: Fungi 847

    19 Eukaryotic Genomes: From Parasites to Primates 887

    20 Human Genome 957

    21 Human Disease 1011

    Glossary 1075

    Self-Test Quiz: Solutions 1103

    Author Index 1105

    Subject Index 1109

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