In this issue of Infectious Disease Clinics of North America, guest editors Drs. Rajesh T. Gandhi and Michael R. Jordan bring their considerable expertise to the topic of Updates on COVID-19. Top experts provide updates on recent advances in diagnosis, treatment, viral protection, and vaccinations, offering infectious disease physicians state-of-the-art clinical and scientific information. With research ongoing and many unanswered questions, this content is key to help stay abreast of current research and clinical information on COVID-19.