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Microbiology of Infectious Disease

Microbiology of Infectious Disease

Integrating Genomics with Natural History

9780192863850
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Description
Prior to the advent of rapid DNA sequencing in the late 90s, students were taught in depth about the physiology and ecology of microorganisms. There was a generally good understanding about the biology of each organism and how it interacted with its environment. Since then, the focus of research has shifted towards an analysis of nucleic acid sequences to determine possible cellular biochemistry or phylogeny. A microbial genome can now be sequenced in a matter of hours, and with thehelp of a panoply of software programmes the inner workings of the organism can be probed in great detail. However, there is now so much detail that the student or researcher tends to lose any sense of the underlying biology of their study organism. Microbiology has almost become a branch ofmolecular biology, with the biology getting lost in the molecular detail. This novel text reverses that trend by cutting through the molecular information overload and placing the new sequence-derived information in the context of the natural history of the organism in question. Each concise chapter has a fascinating and different story to tell, focussing on one pathogen or group of closely related pathogens and highlighting a particularly interesting and/or unusual feature. The aim is to abstract the relevant molecular and genomic information, and then to show howit provides insights into the biology of the organism as a whole. Microbiology of Infectious Disease is aimed at undergraduates, graduates, and researchers in microbiology, microbial ecology, disease ecology, and related areas. It is intended as a supplemental text for students to provide them with a detailed overview of the biology and natural history of the microorganisms they will routinely encounter and the factors that influence their pathogenicity and infectivity.
Product Details
OUP Oxford
93499
9780192863850
9780192863850

Data sheet

Publication date
2022
Issue number
1
Cover
paperback
Pages count
272
Dimensions (mm)
156 x 234
Weight (g)
454
  • Preface; Glossary; Part I:: An Introduction to the Background Science; The role of nucleic acid analysis in understanding infectious diseases; Some common factors involved in host-pathogen relations; The Three Great Pandemics of Plague; Part II:: Bacterial Pathogens; A Multifaceted Pathogen:: Escherichia coli; Fever and Food Poisoning:: The Two Faces of Salmonella; Understanding Pathogen Populations:: Klebsiella pneumoniae; A Surprising Pathogen:: Vibrio cholerae; The Accidental Pathogen:: Legionella pneumophila; Two Related Pathogens, One Ancient and One New; Helicobacter pylori and Gastric Ulcers; A Tale of Two Pathogens:: Pseudomonas aeruginosa and Pseudomonas syringae; The Enigmatic Pathogens:: Syphilis, Yaws, Pinta, and Bejel; Mycobacterial Mysteries:: Tuberculosis and Leprosy; Plasmids and Pathogenicity:: The Bacillus cereus Complex; Tracking the Origins of Clostridium difficile Infections; Tracking Horizontal Gene Transfer:: Staphylococcus aureus; The Inadvertent Pathogen:: Borrelia burgdorferi and Lyme Disease; Phytoplasmas:: Bacteria that Manipulate Plants and Insects; The Most Influential Bacterium:: Wolbachia pipientis; Part III:: Eukaryotic Pathogens; The Ubiquitous Pathogen:: Trichomonas vaginalis; The Greatest Killer of All Times:: The Malarial Parasite; An Environmental Opportunistic Pathogen:: Cryptococcus; The Most Famous Plant Pathogen:: Phytophthora infestans; Part IV; A Virus That Promotes Its Own Transfer:: Tomato Spotted Wilt Virus; Morbilliviruses:: Measles, Rinderpest and Canine Distemper; Filovirus Haemorrhagic Fevers:: Marburg Virus and Ebola; The Origins of HIV and the AIDS Pandemic; The Benefits of a Segmented Genome:: Influenza; Third Time Unlucky:: SARS, MERS, and Covid-19; Part V:: Some Unifying Themes; Zoonotic Diseases; Some Common Pathogenicity Themes;
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