This issue of Immunology and Allergy Clinics, guest edited by Drs. Linda S. Cox and Anna Nowak-Wegrzyn, is devoted to Immunotherapy for Aeroallergens, Foods, and Venoms. Articles in this issue include:: Mechanism of Immunotherapy:: Focus SCIT and SLIT; Subcutaneous Immunotherapy Safety:: Incidence per surveys and risk factors; Sublingual Immunotherapy for Other Indications:: Venom large local, latex, atopic dermatitis and food; Questions and Controversies regarding venom immunotherapy; Socioeconomics or Comparative Effectiveness of Immunotherapy; Risk Reduction in Peanut Immunotherapy; Food OIT with Adjuvants; Peanut OIT:: State of the art; Evolution of Immune Responses in Food Immunotherapy; Safety of Food Oral Immunotherapy:: What we know and what we need to learn; Novel Vaccines for Food Allergy; IgG and IgE in Food Allergy - Whats the connection?; and Sublingual and Patch Immunotherapy for Food Allergy.