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Techniques in Epidermal Biology: An Integrated Approach to Autoimmune Skin Disease

Techniques in Epidermal Biology: An Integrated Approach to Autoimmune Skin Disease

9781612096216
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Description
The high-throughput techniques underlying a systems level analysis of biological organisms have emerged as powerful tools in the study of disease mechanisms. On the other hand, they require substantial funding and multidisciplinary skills. Therefore, basic biochemical/cell biology methods from molecular bioscience are still needed to address key biological questions. This book uses the auto-immune disease Pemphigus Vulgaris (PV) as an experimental model of epidermal disease. Simple molecular bioscience principles and high-throughput methods to clarify disease pathophysiology are presented, which lead to novel therapeutic modalities.
Product Details
Nova Science Publishers Inc
73211
9781612096216
9781612096216

Data sheet

Publication date
2012
Issue number
1
Cover
hard cover
Pages count
182
Dimensions (mm)
230.00 x 155.00
Weight (g)
294
  • Introduction; Current knowledge on pemphigus pathophysiology; Patients, sera, & experimental models; Optimization of the experimental procedures:: Semi-quantitative LCIF microscopy, C-HSU buffer, & KAD medium; Study of Anti-desmoglein autoimmunity:: Pemphigus as a desmoglein-remodeling disease; Role on non-desmoglein & non-igg in pemphigus; Downstream signaling involved in acantholysis:: I. Changes in cell cycle & protein phosphorylation; Downstream signaling involved in acantholysis:: II. Secretion of proteinases & the specific proteolysis; hypothesis of pemphigus; Microarray analysis of diseased tissues:: Cell adhesion is down-regulated on the gene level in pemphigus; Pharmacological block of acantholysis:: Towards novel therapies for the treatment of pemphigus; Index.
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