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Problem-Based Immunology

9781416024163
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Description
Its one thing to understand the basic science of immunology. Its another thing to know how that science applies to the realities of patient care. This new resource uses skillfully presented clinical case studies to efficiently demonstrate the practical relevance of immunology knowledge in diagnosing a wide range of challenging conditions. It offers as an ideal way to review the fundamental principles of immunology ... and see them translated into real-world diagnosis and management!
Product Details
Saunders
35745
9781416024163
9781416024163

Data sheet

Publication date
2006
Issue number
1
Cover
paperback
Pages count
268
Dimensions (mm)
203 x 254
Weight (g)
408
  • IMMUNIZATION

    Background

    . Rationale for immunization
    . General principles of immunization
    . Broad classes of vaccines
    . Role of adjuvants
    . Vaccine efficacy and safety
    . Vaccine strategies in development
    . Novel vaccine applications

    Cases

    1. Deliberate natural immunization (Leishmania)
    2. Immunization in the bioterrorist era; small pox (or anthrax)
    3. Immunization in the elderly (influenza)
    4. Passive immunization: tetanus toxoid
    5. Novel approaches for HIV vaccines
    6. Polio vaccines- Salk versus Sabin
    7. Cancer vaccine

    HYPERSENSITIVITY

    Background

    . General principles
    . Gell and Coombs classifications
    . Sensitization and effector phases of Types I-IV hypersensitivity reactions

    Cases

    8. Anaphylaxis
    9. Asthma
    10. Transfusion reaction
    11. Hemolytic disease of the newborn
    12. Serum sickness
    13. Farmers lung
    14. Tuberculosis
    15. Poison Ivy dermatitis

    AUTOIMMUNITY

    Background

    . General principles of tolerance induction
    . Current evidence/hypothesis for loss of tolerance
    . Evidence supporting a role for genetics in autoimmune disorders
    . Immunopathology associated with autoreactive antibodies
    . Immunopathology associated with T cell mediated damage

    Cases

    16. Rheumatoid arthritis
    17. Systemic lupus erythematosus
    18. Graves disease
    19. Wegeners granulomatosis
    20. Insulin dependent diabetes mellitus
    21. Myasthenia gravis
    22. Multiple sclerosis
    23. Hashimotos thyroiditis

    IMMUNODEFICIENCY DISORDERS

    Background

    . General principles of primary and secondary immunodeficiency disorders
    . Dysfunctions that lead to primary immunodeficiency disorders affecting (a) T cells and B cells combined, (b) T cells, (c) B cells, (d) Complement, (e) phagocytes
    . Conditions that lead to secondary immunodeficiencies

    Cases

    24. Severe combined immunodeficiency disorder
    25. DiGeorges syndrome
    26. Chronic mucocutaneous candidiasis
    27. Brutons agammaglobuliniemia (hypogammaglobulinemia)
    28. Selective IgA deficiency
    29. Hyper IgM syndrome
    30. Chromic granulomatous disease
    31. Hereditary neurotic angioedema
    32. C3 complement deficiency or (C8 complement deficiency)
    33. Leukocyte adhesion defect
    34. Acquired immunodeficiency disorder
    35. Alcoholism and secondary immunodeficiency

    TUMOR IMMUNOLOGY

    Background

    . General principles of tumor immunology
    . Tumor specific antigens
    . Tumor associated antigens
    . Immunosurveillance mechanisms for eliminating tumors
    . Evasion of immunosurveillance
    . Novel therapies

    Cases

    36. Choriocarcinoma (HCG )
    37. Colonic carcinoma (CEA)
    38. Melanoma
    39. Multiple myeloma
    40. Waldenstroms macroglobulinemia
    41. Hodgkins lymphoma
    42. Liver (or testicular) tumor (AFP)

    TRANSPLANTATION

    Background

    . General Features
    . Surgical and ischemia/reperfusion damage
    . Role of activated tissue macrophages and activated vascular endothelial cells
    . Adaptive immunity in graft rejection
    . Tissue matching
    . Non specific Immunosuppression
    . Specific Immunosuppression

    Cases

    43. Intestinal transplant
    44. Pancreas transplant
    45. Kidney transplant
    46. Bone marrow transplant
    47. Heart (or Liver) transplant
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