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Ketogenic Diet and Metabolic Therapies

Ketogenic Diet and Metabolic Therapies

Expanded Roles in Health and Disease

9780190497996
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Description
Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient. Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidencefor emerging applications ranging from autism to Alzheimers disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens.The books editor, Susan A. Masino, brings her unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this one of a kind book, section editors Eric Kossoff, Jong Rho, Detlev Boison, and Dominic P. DAgostino lend their oversight on their respective sections.
Product Details
OUP USA
87838
9780190497996
9780190497996

Data sheet

Publication date
2017
Issue number
1
Cover
hard cover
Pages count
424
Dimensions (mm)
178 x 254
Weight (g)
907
  • Table of Contents; Preface; Contributors List; Section I Ketogenic Diet for Epilepsy in the Clinic; Eric Kossoff, MD, Section Editor; Chapter 1 Overview- Ketogenic Diets and Pediatric Epilepsy: An Update; Eric Kossoff, MD; Chapter 2 Alternative Ketogenic Diets; Elizabeth Neal, RD, MSc, PhD; Chapter 3 Dietary Therapy in Adults: History, Demand, and Results; Emily L. Johnson, MD and Mackenzie C. Cervenka, MD; Chapter 4 How Do You Implement the Diet?; Christina Bergqvist, MD; Chapter 5 Glut1 Deficiency and the KD; Joerg Klepper, MD, PhD; Chapter 6 Ketogenic Diet in Established Epilepsy Indications; Ann Bergin, MD, MB, ScM, MRCP; Chapter 7 Ketogenic Diet for Other Epilepsies; David T. Hsieh, MD and Elizabeth A. Thiele, MD, PhD; Chapter 8 The Ketogenic Diet and Related Therapies in Novel Situations: Idiopathic Generalized Epilepsy Syndromes; Sudha Kilaru Kessler MD, MSCE; Chapter 9 Ketogenic Diet in Status Epilepticus; Rima Nabbout, MD, PhD; Chapter 10 Preventing Side Effects and Diet Discontinuation; Cherie L. Herren, MD and Rana R. Said, MD; Section II Ketogenic Diet - Emerging Clinical Applications and Future Potential; Jong M. Rho, MD, Section Editor; Chapter 11 Overview: Expanded Uses of Ketogenic Therapies; Jong M. Rho, MD; Chapter 12 Metabolism-Based Treatments to Counter Cancer: Scientific Rationale; Thomas N. Seyfried, PhD and Laura Shelton, PhD; Chapter 13 Ketogenic Diet as Adjunctive Therapy for Malignant Brain Cancer; Eric C. Woolf, PhD and Adrienne C. Scheck, PhD; Chapter 14 Metabolic Therapy for Autism Spectrum Disorder and Co-Morbidities; Ning Cheng, PhD, Susan A. Masino, PhD, and Jong M. Rho, MD; Chapter 15 Glucose and Ketone Metabolism in the Aging Brain: Implications for Therapeutic Strategies to Delay the Progression of Alzheimers Disease; Stephen C. Cunnane, PhD, Alexandre Courchesne-Loyer, MSc, Valerie St-Pierre, BSc, Camille Vandenberghe, PhD, Etienne Croteau, PhD, and Christian-Alexandre Castellano, PhD; Chapter 16 Ketogenic Diet and Ketones for the Treatment of Traumatic Brain and Spinal Cord Injury; Femke Streijger, PhD, Ward T. Plunet, PhD, and Wolfram Tetzlaff, MD, Dr.Med, PhD; Chapter 17 Anti-Inflammatory Effects of a Ketogenic Diet: Implications for New Indications; Nina Dupuis, PhD and Stephane Auvin, MD, PhD; Chapter 18 Dietary Therapy for Neurological Disorders: Focus on Amyotrophic Lateral Sclerosis, Parkinsons Disease, Mood Disorders, and Migraine; Carl E. Stafstrom, MD, PhD; Section III Ketogenic Diet in the Laboratory; Detlev Boison, PhD Section Editor; Chapter 19 Overview of Ketogenic Diet in the Laboratory: Progress on Models and Mechanisms; Detlev Boison PhD; Chapter 20 Ketogenic Diet and PPARg; Timothy A. Simeone, PhD; Chapter 21 Ketogenic Diet in a Hippocampal Slice: Models and Mechanisms; Masahito Kawamura, Jr, PhD; Chapter 22 Metabolic Therapy and Pain; David N. Ruskin, PhD; Chapter 23 Ketogenic Diet, Adenosine, Epigenetics, and Antiepileptogenesis; Theresa A. Lusardi, PhD and Detlev Boison, PhD; Chapter 24 Ketogenic Diet, Aging, and Neurodegeneration; Kui Xu, MD, PhD, Joseph C. LaManna, PhD and Michelle A. Puchowicz, PhD; Chapter 25 Endocrine and Reproductive Effects of Ketogenic Diets; Jacob P. Harney, PhD, Kathryn Gudsnuk, MS, Ami Patel, MD Anantha R. Vellipuram, MD, Sathyajit Bandaru, MS and David Butler, MS; Chapter 26 Alzheimers Disease: Causes and Treatment; Richard L. Veech, MD, PhD, DPhil and M. Todd King; Chapter 27 Mitigation of Damage from Reactive Oxygen Species and Ionizing Radiation by Ketone Body Esters; William Curtis, Martin Kemper, PhD, Alexandra Miller, PhD, Robert Pawlosky, PhD, M. Todd King, and Richard L. Veech, MD, PhD, DPhil; Chapter 28 Metabolic Seizure Resistance via BAD and KATP Channels; Juan Ramon Martinez-Francois, PhD, Nika Danial, PhD, and Gary Yellen, PhD; Chapter 29 Lactate Dehydrogenase: A Novel Metabolic Target; Nagisa Sada, PhD and Tsuyoshi Inoue, PhD; Chapter 30 Effects of the Ketogenic Diet on the Blood-Brain Barrier; Manoj Banjara, PhD and Damir Janigro, PhD; Section IV Ketone-Based Metabolism: General Health and Metabolic Alternatives; Dominic P. DAgostino, PhD Section Editor; Chapter 31 Overview of Ketone-Based Metabolism: General Health and Metabolic Alternatives; Dominic P. DAgostino, PhD; Chapter 32 Ketone Supplementation for Health and Disease; Angela M. Poff, PhD, Shannon L. Kesl, PhD, and Dominic P. DAgostino, PhD; Chapter 33 Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet; Matthew C. Walker, PhD and Robin S.B. Williams, PhD; Chapter 34 Triheptanoin in Epilepsy and Beyond; Karin Borges, PhD; Chapter 35 Amino Acids in the Treatment of Neurological Disorders; Adam L. Hartman, MD; Chapter 36 2-Deoxyglucose: Metabolic Control of Seizures through Inhibition of Glycolysis; Carl E. Stafstrom, MD, PhD and Thomas P. Sutula, MD, PhD; Chapter 37 Ketogenic Diets as Highly Effective Treatments for Diabetes Mellitus and Obesity; Eric C. Westman, MD, MHS, Emily Maguire, MSc, and William S. Yancy Jr., MD, MHS; Chapter 38 Keto-Adaptation in Health and Fitness; Parker Hyde, CSCS, CISSN, Vincent J. Miller, PhD, and Jeff S. Volek, PhD, RD; Chapter 39 Advancing the Awareness and Application of Ketogenic Therapies Globally: The Charlie Foundation and Matthews Friends; Beth Zupec-Kania, RD, CD, Jim Abrahams, Emma Williams, MBE, Susan A. Masino, PhD;
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