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Histone Deacetylase Inhibitors (HDIs): Pharmacology, Uses & Health Effects
9781634638357
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Description
Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.
Product Details
74807
9781634638357
9781634638357
Data sheet
- Publication date
- 2015
- Issue number
- 1
- Cover
- hard cover
- Pages count
- 95
- Dimensions (mm)
- 155.00 x 230.00
- Weight (g)
- 302
- Preface; Classification & Function of Histone Deacetylase Inhibitors; Histone Deacetylase Inhibitors in the Treatment of Lymphoid Malignancies; Histone Deacetylase Inhibitors in the Treatment of Myeloid Malignancies; Histone Deacetylase Inhibitors for Breast Cancer:: Driving Out of Stemness; Index.
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