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Histone Deacetylase Inhibitors (HDIs): Pharmacology, Uses & Health Effects

Histone Deacetylase Inhibitors (HDIs): Pharmacology, Uses & Health Effects

9781634638357
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Description
Histone deacetylase inhibitors (HDIs) are good anti-cancer targets. Histone acetyltransferases (HATs) and HDIs play opposite roles in the regulation of gene expression via an epigenetic mechanism. HATs catalyse the acetylation of lysine residues in histone tails, facilitating and sustaining gene transcription. HDIs remove the acetyl moieties from the epsilon-amine of lysine residues of histone tails, leading to a more condensed form of chromatin and preventing gene transcription. This book focuses on the use of HDIs for the treatment of lymphoid malignancies; myeloid malignancies; and breast cancer.
Product Details
Nova Science Publishers Inc
74807
9781634638357
9781634638357

Data sheet

Publication date
2015
Issue number
1
Cover
hard cover
Pages count
95
Dimensions (mm)
155.00 x 230.00
Weight (g)
302
  • Preface; Classification & Function of Histone Deacetylase Inhibitors; Histone Deacetylase Inhibitors in the Treatment of Lymphoid Malignancies; Histone Deacetylase Inhibitors in the Treatment of Myeloid Malignancies; Histone Deacetylase Inhibitors for Breast Cancer:: Driving Out of Stemness; Index.
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