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Molecular Hematology

Molecular Hematology

9781394180455
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Description

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated

Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more.

Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout.

  • Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies
  • Illustrates the impact of molecular research on hematologic investigations and therapeutics
  • Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders
  • Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma
  • Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools

Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Product Details
Wiley-Blackwell
101479
9781394180455

Data sheet

Publication date
2024
Issue number
5
Cover
hard cover
Pages count
448
Dimensions (mm)
221.00 x 280.00

  • List of contributors ix

    Foreword xiii

    Preface xv

    1 Beginnings: the molecular pathology of hemoglobin 1
    Douglas Higgs and Mohsin Badat

    2 Stem cells 17
    David T. Scadden

    3 The genetics of acute myeloid leukemia 33
    Amye M. Harrigan and Amy M. Trottier

    4 Molecular diagnostics and risk assessment in myeloid malignancies 51
    Christian Scharenberg and Torsten Haferlach

    5 Molecular basis of acute lymphoblastic leukemia 67
    Shunsuke Kimura and Charles G. Mullighan

    6 Chronic myelogenous leukemia 83
    Hagop Kantarjian, Elias Jabbour and Susan O’Brien

    7 Myeloproliferative neoplasms 99
    Jessica Spiers, Dina Mahdi, Christopher Saunders and Donal P. McLornan

    8 Lymphoma genetics 113
    Giovanni Insuasti- Beltran, Chad M. McCall and Eric D. Hsi

    9 Molecular basis of chronic lymphocytic leukemia 127
    Bita Fakhri and Alexey Danilov

    10 The molecular biology of multiple myeloma 137
    Udit Yadav and Wilson I. Gonsalves

    11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 145
    Deena Iskander, Lucio Luzzatto and Anastasios Karadimitris

    12 Anemia of chronic disease 169
    Tomas Ganz and Elizabeta Nemeth

    13 Molecular basis of iron metabolism 175
    Jodie L. Babitt and Tomas Ganz

    14 Perspectives in genomics and sickle cell disease therapeutics 187
    Ambroise Wonkam

    15 Molecular coagulation and thrombophilia 201
    Björn Dahlbäck and Andreas Hillarp

    16 The molecular basis of hemophilia 217
    Keith Gomez

    17 The molecular basis of von Willebrand disease 231
    Omid Seidizadeh and Luciano Baronciani

    18 Platelet disorders 251
    Kenneth J. Clemetson

    19 The molecular basis of blood cell alloantigens 267
    Winnie Chong, Louise Tilley and Colin Brown

    20 Functions of blood group antigens 285
    Jonathan S. Stamler, Marilyn J. Telen and Carla Dinardo

    21 Autoimmune hematological disorders 299
    Drew Provan and John W. Semple

    22 Molecular therapeutics in hematology: gene therapy 321
    William M. McKillop and Jeffrey A. Medin

    23 Pharmacogenomics 343
    Leo Kager and William E. Evans

    24 Cancer stem cells 359
    Sara Ali and Dominique Bonnet

    25 CAR- T cell therapy 369
    Jude Franklin, Prateek Pophali, Zachary Jackson, David Wald and David Avigan

    26 Molecular basis of transplantation 397
    Pramila Krishnamurthy, Victoria Potter and Francesco Dazzi

    Index 413

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