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Aplastic Anemia: Pathophysiology and Treatment

Aplastic Anemia: Pathophysiology and Treatment

9780521641012
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Description
This book takes account of the most recent findings in laboratory research and clinical trials to provide a comprehensive and up-to-date reference on the pathophysiology, epidemiology, diagnosis and treatment of acquired and inherited aplastic anemia. As well as a detailed overview of the pathophysiology of the disease, the international team of authors cover all aspects of management, including the established approaches of bone marrow transplantation and immunosuppressive treatment, new approaches such as the use of hematopoietic growth factors and escalated immunosuppression, and controversial issues such as stem cell transplantation. Also included is an important international consensus document on treatment, and a final section concentrates on the inherited syndrome Fanconis anemia. Detailed treatment guidelines are given, making this the definitive resource for hematologists and other clinicians involved in the management and supportive care of patients with aplastic anemia. Scientists interested in bone marrow failure will also find this an invaluable reference.
Product Details
Cambridge University Press
97537
9780521641012
9780521641012

Data sheet

Publication date
1999
Issue number
1
Cover
hard cover
Pages count
403
Dimensions (mm)
193.00 x 255.00
Weight (g)
1105
  • Part I. Pathophysiology of Acquired Aplastic Anemia:: 1. Stem cell defect in aplastic anemia J. C. W. Marsh and N. G. Testa; 2. Cytokine abnormalities in aplastic anemia S. Kojima; 3. Role of T-lymphocytes and apoptosis in pathophysiology of aplastic anemia S. Nakao; 4. Role of apoptosis in pathophysiology of aplastic anemia F. M. Gibson, N. J. Philpott, J. C. W. Marsh and E. C. Gordon-Smith; 5. Interrelation between aplastic anemia and paroxysmal nocturnal hemoglobinuria G. Socie, J.-Y. Mary, H. Schrezenmeier and E. Gluckman; 6. Aplastic anemia and other clonal disorders A. Raghavachar; Part II. Epidemiology and Clinical Features of Acquired Aplastic Anemia:: 7. Epidemiology and etiology of aplastic anemia H. Heimpel; 8. Clinical presentation, natural course and prognostic factors P. Marin-Fernandez; Part III. Treatment of Acquired Aplastic Anemia:: 9. Supportive treatment of patients with severe aplastic anemia P. Ljungman; 10. Immunosuppressive treatment of aplastic anemia A. Bacigalupo, H. Schrezenmeier and A. Tichelli; 11. Role of cytokines in the treatment of aplastic anemia H. Schrezenmeier; 12. HLA-identical sibling bone marrow transplantation to treat severe aplastic anemia S. R. McCann, J. R. Passweg, R. Storb and H. J. Deeg; 13. Alternative donor bone marrow transplantation for severe acquired aplastic anemia J. M. Hows, J. V. Stone and B. M. Camitta; 14. Treatment of children with acquired aplastic anemia A. Locasciulli; 15. Long-term follow up of patients with aplastic anemia A. Tichelli and G. Socie; 16. Guidelines for treatment of aplastic anemia (international consensus document); Part IV. Fanconis Anemia:: 17. Clinical features and diagnosis of Fanconis anemia B. P. Alter; 18. Genetic basis of Fanconis anemia M. Buchwald and M. Carreau; 19. Treatment of Fanconis anemia E. Gluckman, G. Socie and P. Guardiola; 20. Genetic correction of Fanconis anemia J. M. Liu.
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