• Order to parcel locker

    Order to parcel locker
  • easy pay

    easy pay
  • Reduced price
The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models

The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models

9780521254649
1,001.70 zł
901.53 zł Save 100.17 zł Tax included
Lowest price within 30 days before promotion: 901.53 zł
Quantity
Available in 4-6 weeks

  Delivery policy

Choose Paczkomat Inpost, Orlen Paczka, DPD or Poczta Polska. Click for more details

  Security policy

Pay with a quick bank transfer, payment card or cash on delivery. Click for more details

  Return policy

If you are a consumer, you can return the goods within 14 days. Click for more details

Description
This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function. The book begins with an exploration of several human autosomal aneuploid phenotypes, with particular emphasis on the relationship between genotype and phenotype. In the next part, broad theoretical considerations of the mechanisms which generate these phenotypes are examined with reference to studies on man and other organisms such as bacteria and mice. Experimental approaches to study the effects of aneuploidy are presented next with special attention paid to the development of model systems for studying human aneuploidy.
Product Details
98838
9780521254649
9780521254649

Data sheet

Publication date
1986
Issue number
1
Cover
hard cover
Pages count
510
Dimensions (mm)
156.00 x 234.00
Weight (g)
960
  • Preface; Glossary; Part I. Introduction:: 1. The problem of aneuploidy; Part II. Clinical Observations:: 2. The differentiability and variability of phenotypes; 3. The partitioning of phenotypes; Part III. The Theoretical Mechanisms and Issues:: The Primary and Secondary Effects of Aneuploidy:: 4. Gene dosage effects; 5. Metabolic pathways, transport systems and receptors; 6. Regulatory systems; 7. Assembly of macromolecules, cellular interactions and pattern formation; 8. Type and countertype; 9. Nonspecific effects of aneuploidy; Part IV. Experimental Systems for the Study of Mammalian and Human Aneuploidy:: 10. Generation and properties of mouse aneuploids; 11. Models for human aneuploidy; Part V. Three Major Clinical Problems of Human Aneuploidy:: 12. Trisomy 21 (Down syndrome); 13. Monosomy X (Turner syndrome, gonadal dysgenesis); 14. Cancer; Part VI. Conclusion:: 15. Principles, mechanisms and models; Appendix; References; Index.
Comments (0)