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Human Genetic Diversity
Functional Consequences for Health and Disease
9780199227693
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Description
The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning of a long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field promises much:: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Contemporary genetic research isallowing the basis of both rare inherited disorders and common multifactorial diseases like asthma and diabetes to be more clearly defined. Huge investments are being made and great advances have been achieved, but the challenges remain daunting. This book provides an authoritative overview of thistopical and very rapidly advancing field of biomedical research.Human Genetic Diversity describes the major classes of genetic variation and their functional consequences. A combination of cutting-edge research and landmark historical studies illustrate developments in the field, the rationale for current studies and likely future directions. Major structural variants at a chromosomal level are described, as well as copy number variation and sequence level genetic diversity. Evidence of selective pressures in human populations and insights intohuman evolution are illustrated. The book describes the development of linkage analysis and more recently genome-wide association studies to define the genetic basis of disease, current approaches to defining functional causative variants and the emerging fields of pharmacogenomics and individualised medicine.
Product Details
86392
9780199227693
9780199227693
Data sheet
- Publication date
- 2009
- Issue number
- 1
- Cover
- hard cover
- Pages count
- 504
- Dimensions (mm)
- 195 x 253
- Weight (g)
- 1285
- Lessons From Haemoglobin; Finding Genes and Specific Genetic Variants Responsible for Disease; Cytogenetics and Large Scale Structural Genomic Variation; Submicroscopic Structural Variation in Health and Susceptibility to Disease; Submicroscopic Structural Variation and Genomic Disorders; Segmental Duplications and Indel Polymorphisms; Tandem Repeats; Mobile DNA Elements; SNPs, HapMap and Common Disease; Fine Scale Sequence Diversity and Signatures of Selection; Genetics of Gene Expression; Extreme Diversity in the Major Histocompatibility Complex; Parasite Wars; Human Genetic Diversity and HIV:: Lessons From a War Fought on Many Fronts; Concluding Remarks and Future Directions; Glossary; References; Index;
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