Non-Mendelian Genetics in Humans

When rediscovered at the turn of the century, Mendels laws were found to be applicable to humans, but from the beginning they were fraught with problems. Sex-linked traits and linked genes defied Mendels rules. Later, other exceptions were found, including sporadic cases, non-penetrance, variable expressivity, and preferential parental transmission. In this book, Harry Ostrer observes that some of these problems can be explained by incomplete ascertainment, typing errors and modifying genes. He then goes on to systematically explore the evidence for a number of newer genetic processes that were not foreseen by Mendel and his intellectual heirs, examining the molecular basis for these processes and their effects on transmission and phenotype. He shows that these non-Mendelian processes—gonadal and somatic mosaicism, sex-linkedinheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection—resolve many of the exceptions to Mendelian inheritance. He also provides a complete review of Mendelian genetics, as well as an overview of the structure and functions of genes, chromosomes, andtheir products. Thus the book presents a holistic view of human genetics. In the last chapter, Ostrer grapples with the possibilities for identifying new genetic processes, and with genetic determinism—the view that a persons phenotype is fully subject to his or her genetic constitution. He contends that despite the large number of genetic combinations, phenotypes cannot be predicted precisely, even with sufficient computing power. Genetic processes are frequently modified by environmental exposure or they may be random or stochastic in their occurrence. Hence,there are innate limits to genetic determinism. Although prediction of phenotype based on genotype will improve in the future as all of the human genes are identified, such predictions will always remain imprecise.