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Transcription Factors and Human Disease

Authors:

Gregg L. Semenza

Brand: OUP USA

ISBN: 9780195112399

283.44 zł

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Description

Transcription factors are essential mediators of the genetic programs that control development and physiology. This exciting book presents current knowledge of transcription factors from two viewpoints. First, the basic science of transcriptional regulation is discussed. Second, inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites are described. Readers are also introduced to the involvement oftranscription factors in somatic cell genetic disease (cancer) and epigenetic disease (teratogenesis).

Product Details

Brand OUP USA

Reference 83983

EAN13 9780195112399

ISBN 9780195112399

Data sheet

Publication date: 1998
Issue number: 1
Cover: hard cover
Pages count: 382
Dimensions (mm): 165 x 245
Weight (g): 910

Part I:: Transcriptional Regulation; Gene Expression and Transcriptional Regulation; Cis-acting Transcriptional Regulatory Elements; Trans-acting Factors; Part II:: Transcriptional Pathophysiology; Mutations in Cis-acting Transcriptional Regulatory Elements; Mutations in Genes Encoding Transcription Factors:: The Nuclear Receptor Superfamily; Other Zinc-Finger Proteins:: WT1 and GL13; PAX Proteins; bHLH Proteins; Homeodomain Proteins; HMG Domain Proteins; POU Domain Proteins; Other Transcriptional Factor Families; Co-activators; General Transcription Factors; Somatic Cell Genetic Disease:: Cancer; Epidenetic Disease:: Teratogenesis;

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Author: Richard C. Allen

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Transcription Factors and Human Disease

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