This book looks at genotoxicity which is a deleterious action on cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumours. In humans, DNA damage or genotoxicity may be caused by exposure to outside agents like radiation, pesticides, combustion of hydrocarbon products as well as antineoplastic drugs. DNA damage could also come from inside of the body, determined mainly by excessive free radical production generated by some disease process. The importance then, is to identify the genotoxity and try to protect the body, which may be as simple as removing the source of exposure or providing protection against such agents. This new important book gathers the latest research from around the globe in this dynamic field of study.
Preface; The Importance of the In Vitro Genotoxicity Evaluation of Food Components:: The Selenium; In Vitro High-throughput Assays for Assessment of Genetic Toxicology; Genotoxicity Evaluation of Exposure to Lead; Genotoxicity Produced by Disease and Drugs; Co-Mutagenic Effects of Nifedipine and Diltiazem In Vivo; Usefulness of Bulky DNA Adduct Formation as a Biological Marker of Exposure to Airborne Particulate Matter (Pm2.5) in In Vitro Cell Lung Models:: A Comparative Study; Impact Assessment and Evaluation of Cadmium-Induced Genotoxicity and Clastogenicity in Mice; Loss of Heterozygosity and/or Microsatellite Instability in Multiple Critical Regions of 3p and 9p Chromosomes in Human Epithelial Lung Cells (L132) Exposed to Air Pollution Particulate Matter (Pm2.5); Prediction of the Human Radiosensitivity:: What is the Most Relevant Endpoint? Gene Expressions, Mutations or Functions?; Application of Genotoxicity to Dental Materials Research; Use of the Comet Assay to Evaluate Pesticide Toxicity on Non-Target Microalgae; Numberless drugs are not adequately tested for the potential genotoxic-carcinogenic risk to humans; Index.
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