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Molecular Genetic Testing in Surgical Pathology

Molecular Genetic Testing in Surgical Pathology

9780781747486
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Description

Written by experts from Washington University School of Medicine, this text is a thorough review of the specific molecular genetic techniques that can provide diagnostically useful molecular genetic information on tissue samples—including cytogenetics, fluorescence in situ hybridization (FISH), PCR, electrophoresis and hybridization analysis, DNA sequence analysis, and microarrays. The first part of the book describes each technique, indicates its advantages, disadvantages, capabilities, and limitations, and systematically addresses sensitivity and specificity issues. Subsequent chapters, organized by organ system, detail the specific applications of these tests in surgical pathology. More than 150 full-color and black-and-white illustrations complement the text.

Product Details
Lippincott Williams & Wilkins
42563
9780781747486
9780781747486

Data sheet

Publication date
2005
Issue number
1
Cover
hard cover
Pages count
473
Dimensions (mm)
216 x 279
Weight (g)
1606
  • 1 Structure and Function of DNA and RNA 1

    2 DNA Damage, Mutations, and Repair 29

    3 Cytogenetics 58

    4 Fluorescence in situ Hybridization 72

    5 Polymerase Chain Reaction 86

    6 Nucleic Acid Electrophoresis and Hybridization 111

    7 DNA Sequence Analysis 123

    8 Sensitivity and Specificity Issues 140

    9 Microarrays 152

    10 Clinical Testing of Patients Specimens 171

    11 Tumors of Soft Tissue and Bone 186

    12 Endocrine System 232

    13 Molecular Diagnostics in Hematopathology 250

    14 Neural Tumors and Neuromuscular Diseases 275

    15 Gastrointestinal Tract 294

    16 Reproductive Organs 322

    17 Urinary Tract 345

    18 Skin 367

    19 Lung and Mediastinum 380

    20 Breast 401

    21 Head and Neck 415

    22 Infectious Diseases 426

    23 Identity Determination 440

    24 The Future 451

    Appendix 1 Genetic Codes 459

    Appendix 2 Amino Acids 461

    Appendix 3 Summary of Recommended Nomenclature for Describing Mutations 462

    Subject Index 464

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