101 Medical Autopsy Cases: Adult & Pediatric

Introduction
Medical Autopsy:: The Strongest Teaching Tool in Medicine
Section 1:: Hematological Disorders-Adult Cases
Case 1:: Mantle Cell Lymphoma, Presenting with Florid Cutaneous Lesions, with Common Variant Morphology in the Nodal/Extranodal Sites and Blastoid Morphology in the Peripheral Blood::PM 25983
Case 2:: Primary Myelofibrosis, Cellular Phase with Formation of Sclerosing Extramedullary Hematopoietic Tumors:: PM 27873
Case 3:: Primary Myelofibrosis, Cellular Phase with Extensive Extramedullary Hematopoiesis and Transformation into Acute Leukemia:: PM 23618
Case 4:: Hepatosplenic T-cell Lymphoma:: PM 23096
Case 5:: Acute Promyelocytic Leukemia with Early Death due to Disseminated Intravascular Coagulation and Right Temporal Lobe Hemorrhage:: PM 26880
Case 6:: Acute Promyelocytic Leukemia with Differentiation Syndrome:: PM 17959
Case 7:: Chronic Lymphatic Leukemia, Post-Bone Marrow Transplantation with Recurrence, Massive Lymphadenopathy and Hemophagocytosis:: PM 21710
Case 8:: Symptomatic Plasma Cell Myeloma with Primary Systemic Amyloidosis Showing a Predominant Involvement of the Heart and Gastrointestinal Tract:: PM 19667
Section 2:: Malignancy-Adult Cases
Case 9:: Microscopic/Occult Testicular Seminoma with Germ Cell Neoplasia in situ and Widespread Nonseminomatous Metastasis in a Young Male:: PM 14170
Case 10::Malignant Teratoma, Primary Pulmonary, Containing Yolk Sac tumor, Associated with Hematologic Neoplasia:: PM 13633
Case 11::Young Male with Metastasis:: Do not Waste Time-Look for the Primary in the Testes:: PM 19388
Case 12:: Occult, Peripheral, Mucin-secreting Adenocarcinoma of Lung with Florid Meningeal Carcinomatosis along with Thrombotic Microangiopathy and Disseminated Intravascular Coagulation, Leading to Bilateral Renal Infarction:: PM 26226
Case 13:: Young Male with Occult, Diffuse Type, Mucin-secreting Adenocarcinoma of the Stomach with Extensive Lymphangitic Carcinomatosis, Presenting with Deep Vein Thrombosis and Pulmonary Embolism:: PM 21829
Section 3:: Infections-Adult Cases
Case 14:: Amebic Ileocolitis, Perforation and Liver Abscess:: PM 18836
Case 15:: Cerebral Toxoplasmosis in a Human Immunodeficiency Virus Positive Patient:: PM 19210
Case 16:: Pulmonary Hyalinizing Granuloma with Recent Onset Cryptococcal Meningoencephalitis in an Immunocompetent Male:: PM 21122
Case 17:: Leptospirosis with Multiorgan Involvement:: PM 22793
Case 18:: Silicotuberculosis:: PM 26075
Case 19:: Rabies Meningoencephalitis, Post-Pet Dog Bite:: PM 27786
Section 4:: Hepatobiliary and Pancreatic Disorders-Adult Cases
Case 20:: Extrahepatic Portal Venous Obstruction due to Cavernomatous Transformation of Portal Vein and Portal Cavernoma Cholangiopathy:: PM 22260
Case 21:: Chronic Budd-Chiari Syndrome with Mesoatrial Shunt, Venocentric Cirrhosis, Hepatocellular Carcinoma Infiltrating into the Hepatic Duct Causing Obstruction and Hemobilia:: PM 27800
Case 22:: Acute on Chronic Pancreatitis Leading to Portal Vein Pyemia, with Multiple Liver Abscesses and Life-threatening Sepsis Shock:: PM 25975
Case 23:: Lipomatous Pseudohypertrophy of the Pancreas with Polyglandular Autoimmune Syndrome Type II and Inflammatory Myopathy:: PM 22590
Case 24:: Young Male with Early Onset Micronodular Cirrhosis due to Synergistic Hepatotoxic Effect of Alcohol and Hepatitis C Virus Infection along with Cryoglobulinemic Vasculitis:: PM 27791
Case 25:: Diffuse Hepatocellular Carcinoma Arising in a Setting of Mixed Nodular Cirrhosis, Hepatitis C Virus and Alcohol Related:: PM 26695
Case 26::Acute Liver Failure and Encephalopathy in a Case of Dengue Shock Syndrome:: PM 25035
Case 27:: Postpartum, Hyperacute, Fulminant Hepatic Failure due to Hepatitis E Virus:: PM 26595
Case 28:: Sporadic, Hepatitis E-related Massive Hepatic Necrosis in a Young Female:: PM 26254
Case 29:: A Classical Case of Wilsons Disease with Hepatic and Neuropsychiatric Manifestations:: PM 26195
Section 5:: Cardiovascular System-Adult Cases
Case 30:: Silent Healed Myocardial Infarction and its Complications-Infarct Expansion, Mural Thrombosis, Aneurysm Formation, Extensive Arterial Embolization, Deep Vein Thrombosis and Subsequent Fatal Venous Thromboembolism:: PM 21817
Case 31:: Coexistence of Acute-on-Chronic Rheumatic Heart Disease and Acute Poststreptococcal Glomerulonephritis:: PM 21119
Case 32:: A Classical Case of Marfan Syndrome with Aortic Root Dilatation, Aneurysm of the Ascending Aorta and Acute Aortic Dissection:: PM 22554
Case 33:: Adult Tetralogy of Fallot with Tricuspid Valve Infective Endocarditis and Thromboembolic Botryomycotic Cerebral Abscess:: PM 26941
Case 34:: Cocaine-induced Vasculopathy Leading to Cardiomyopathy, Renal Infarcts, Gangrene of Digits with Autoamputation:: PM 23445
Case 35:: Aftermath of Hypertension in a Middle-aged Male-Intraparenchymal Brain Hemorrhage, Pontine and Thalamic:: PM 26485
Section 6:: Systemic Vasculitides-Adult and Pediatric Cases
Systemic Vasculitides-Introduction
Small Vessel Vasculitides
Case 36:: Renal Limited Microscopic Polyangiitis:: PM 13127
Case 37:: Microscopic Polyangiitis, ANCA Negative, with Florid Glomerulitis and Granulomatous Glomerulonephritis:: PM 15649
Case 38:: Microscopic Polyangiitis in a Child:: PM 16450
Case 39:: Microscopic Polyangiitis, ANCA Negative, Clinically Mimicking Granulomatosis with Polyangiitis (Wegeners Granulomatosis) and Presenting with a Breast Mass:: PM 18473
Case 40:: Microscopic Polyangiitis-Chronic Phase:: PM 18987
Case 41:: Microscopic Polyangiitis with Acute Vasculitis of Small, Medium and Large-sized Arteries:: PM 20415
Case 42:: p-ANCA Positive Classic Polyarteritis Nodosa:: PM 24277
Case 43:: Takayasus Aortoarteritis, Pulmonary Hypertension, and Pulmonary Capillary Hemangiomatosis:: PM 14993
Case 44:: Takayasu Aortoarteritis, Presenting with Pulmonary Arterial Hypertension Secondary to Extensive Involvement of Right Pulmonary Artery:: PM 25988
Case 45:: Granulomatosis with Polyangiitis (Wegeners Granulomatosis) with Left Foot Gangrene and Right Hemiplegia:: PM 14106
Case 46:: Granulomatosis with Polyangiitis-Wegeners Granulomatosis, Presenting as an Anterior Mediastinal Mass:: PM 18613
Case 47:: Granulomatosis with Polyangiitis, i.e Wegeners with Multiple Pulmonary Nodules and Total Splenic Necrosis:: PM 21594
Case 48:: c-ANCA Positive, Nonreactive, Disseminated Tuberculosis with Pulmonary and Mesenteric Vasculitis:: PM 14513
Section 7:: Primary Renal Mucormycosis-Adult and Pediatric Cases
Case 49:: Isolated Bilateral Renal Mucormycosis with Contiguous Spread to the Adrenals, Mesentery, Pancreas and Colon in an Apparently Immunocompetent Adult:: PM 27250
Case 50:: Primary Bilateral Renal Mucormycosis in an Apparently Immunocompetent Child:: PM 22863
Section 8:: Histiocytosis-Pediatric and Adult Cases
Case 51:: Primary/Familial Hemophagocytic Lymphohistiocytosis with Extensive Involvement of the Brain:: PM 20788
Case 52:: Langerhans Cell Histiocytosis Presenting as an Anterior Mediastinal Mass:: PM 21476
Case 53:: Macrophage Activation Syndrome-A Fatal Complication of Systemic Onset Juvenile Idiopathic Arthritis:: PM 26202
Case 54:: Epstein-Barr Virus-associated Secondary Hemophagocytic Lymphohistiocytosis-
A Rare Complication:: PM 21703
Section 9:: Primary Immunodeficiency-Pediatric Cases
Case 55:: Disseminated Bacillus Calmette-Guerin Infection in a Case of Severe Combined
Immunodeficiency:: PM 22931
Case 56:: Chronic Granulomatous Disease of Childhood:: PM 24170
Case 57:: Disseminated Nonreactive Tuberculosis, PCR-Proven Dual Positivity for Mycobacterium Tuberculosis and Abscessus ? Mendelian Susceptibility to Mycobacterial Disease:: PM 25174
Section 10:: Infantile Nephrotic Syndrome
Case 58:: Congenital Nephrotic Syndrome of the Finnish Type:: PM 23777
Case 59:: Infantile Nephrotic Syndrome-Diffuse Mesangial Sclerosis in a 10-Month-Old Male Child:: PM 26462
Section 11:: Infections-Pediatric Cases
Case 60:: Disseminated Congenital Cytomegalovirus Infection with Islet Cell Hyperplasia as the Cause of Persistent Hypoglycemia in a Neonate:: PM 23822
Case 61:: Congenital Tuberculosis:: An Underdiagnosed Entity:: PM 24753
Case 62:: Disseminated Cryptococcomas Mimicking Disseminated Malignancy, with Hepatic Dysfunction as the Initial Manifestation, in an Immunocompetent Child:: PM 25744
Introduction to Tubercular Meningitis
Case 63:: Catastrophic Posterior Circulation Tubercular Arteritis with Infarcts and Cortical
Venous Thrombosis-A Rare Co-existence:: PM 26344
Case 64:: Child with Disseminated Miliary Tuberculosis, Tubercular Meningitis with
Extensive Arteritis, Infarction and Ischemic Hepatitis:: PM 25901
Case 65:: Disseminated Cryptococcal Infection in an HIV-positive Child:: PM 23563
Section 12:: Cardiovascular System-Pediatric Case
Case 66:: Transposition of Great Arteries:: PM 24027
Section 13:: Hematological Disorders-Pediatric Cases
Case 67:: Child with Acute Lymphoblastic Leukemia on Induction Therapy with Febrile
Neutropenia and Disseminated Aspergillus Infection:: PM 25927
Case 68:: Myeloid Sarcoma of Lacrimal Sac as the First Manifestation of AML-M1 with Acute Diffuse Colorectal Neutropenic Colitis in a Child:: PM 23395 576
Section 14:: Storage Disorder
Case 69:: Niemann-Pick Type B Presenting with Massive Splenohepatomegaly and Hypertensive Crisis in a 12-year-old Child:: PM 27096
Section 15:: Pediatric Renal Cystic Disease (Developmental/Genetic/Syndromes)
Pediatric Cystic Disease (Developmental/Genetic) of Kidney-Introduction
Section 15A:: Renal Dysplasia
Case 70:: Recurrent Bilateral Multicystic Dysplastic Kidneys, Consistent with Hereditary
Renal Adysplasia:: PM 20505
Case 71:: Symmetrically Enlarged, Solid Dysplastic Kidneys with Intrauterine Growth
Retardation:: PM 24340
Case 72:: Multicystic Dysplastic Kidneys with Dilated Ureters and Hypertrophied Urinary
Bladder Leading to Obstructed Labor and Uterine Rupture:: PM 26207
Case 73-74:: Renal Hypodysplasia:: PM 19521, PM 25711 619
Nandita Bharadwaj Kakkar
Case 75:: Bilateral Renal Agenesis:: PM 24019
Case 76-80:: Unilateral Renal Malformation:: PM 22428, PM 22393, PM 26428, PM 26291, PM 26824
Case 81:: Segmental Renal Dysplasia with Duplex Kidney and Ureterocele:: PM 19965
Section 15B:: Posterior Urethral Valve
Case 82-83:: Posterior Urethral Valve Leading to Congenital Hydroureteronephrosis and
Hypertrophied Urinary Bladder:: PM 18485, PM 26118
Section 15C:: Renal Hypoplasia
Case 84:: Neonate with Bilateral Simple Renal Hypoplasia, Lung Hypoplasia and Hydrocephalous:: PM 27245
Case 85:: Bilateral Simple Renal Hypoplasia, Cystic Periventricular Leukomalacia with Hydrocephalus ex vacuo in Surviving Twin, after death of Monochorionic Co-twin:: PM 25677
Case 86:: Segmental Hypoplasia (Ask-Upmark Kidney):: S-14525/2008
Section 15D:: Genetic Disorders
Case 87:: A Classical Case of Autosomal Recessive Polycystic Kidney Disease:: PM 22879
Case 88:: Autosomal Dominant Polycystic Kidney Disease with Cyst Infection:: PM 22828
Section 15E:: Glomerulocystic Kidney Disease
Case 89:: Co-existing Glomerulocystic Kidney Disease and Renal Tubular Dysgenesis with Late Onset Oligohydramnios and Renal Failure at D2 of Life:: PM 28154
Case 90:: Glomerulocystic Kidney Associated with Posterior Urethral Valve- A Rare Association:: PM 28255
Section 15F:: Syndromes
Case 91-92:: Meckel-Gruber Syndrome:: PM 20070, PM 26190
Case 93-94:: Prune Belly Syndrome Leading to a Markedly Distended Urinary Bladder and
Hydroureteronephrosis:: PM 23424, PM 25509
Case 95:: Sirenomelia with Bilateral Renal Agenesis and Multiple Other Malformations:: PM 27025
Section 16:: Liver Disorders-Pediatric Cases
Case 96:: Coexistence of Duarte 2 Variant of Galactosemia with Niemann-Pick Disease Type B, in an Infant:: PM 23108
Case 97:: A Classical Case of Galactosemia:: PM 23869
Case 98:: Galactosemia, Double Heterozygous for N314D and Q188R Mutations, with
Micronodular Cirrhosis and Absence of Steatosis:: PM 25342
Case 99:: A Case of Galactosemia, Double Heterozygous for Q188R and E308K Mutations with Early Neonatal Acute Liver Failure:: PM 25552
Case 100:: Neonate with Hemolytic Disease of Newborn (Due to Rh Isoimmunization-for both Rh-D Antigen and Rh-C Antigen), Conjugated Hyperbilirubinemia, and Associated Nonsyndromic Paucity of Intrahepatic Bile Ducts:: PM 27937
Case 101:: Indian Childhood Cirrhosis:: PM 24527
Abbreviations
Index