In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Amy E. Hosmer brings her considerable expertise to the topic of Endoscopic Closure Techniques. These techniques provide minimally invasive solutions for managing gastrointestinal perforations, leaks, and fistulas, and offer a safer and more efficient alternative to traditional surgical interventions, reducing patient morbidity and recovery time. Recent advancements in endoscopic devices and materials have expanded the therapeutic capabilities of GI endoscopists, allowing for precise and reliable closure of even complex lesions. This issue provides current, state-of-the-art clinical reviews on endoscopic closure techniques to facilitate better patient outcomes.