Emergencies involving disorders of the liver are a continuing medical priority and, with stable pancreatitis rates, increased alcohol use globally, increased exposure to other toxins, and widespread hepatitis B and C, they can be expected to remain so. This issue of Medical Clinics of North America contains the following nine articles:: Acute Liver Failure Including Acetaminophen Overdose; The Hepatorenal Syndrome; Hepatic Disorders Mildly to Moderately affected by Pregancy; Management of Chromic Liver Failure Until Liver Transplantation; Choledocholithiasis, Ascending Cholangitis, and Gallstone Pancreatitis, Minimally Invasive and Standard Surgical Therapy for Complications of Pancreatitis and for Benign Tumors of the Pancreas and Duodenal Papilla; Hepatic Encephalopathy; Medical and Obstetric Management of Hepatic Disorders Severely Affected by Pregnancy; and Liver Transplantation for Liver Failure.