In collaboration with Consulting Editor, Dr. Charles J. Lightdale, Guest Editor Dr. Sachin Wani has put together a state-of-the art issue that presents the latest advances in Barretts Esophagus. He has secured expert authors who have contributed clinical reviews on the following topics:: The epidemiology of Barretts esophagus and esophageal adenocarcinoma - implications for screening and surveillance; Endoscopic screening for Barretts esophagus and esophageal adenocarcinoma:: rationale, candidates and challenges; Progress in screening for Barretts esophagus:: beyond standard upper endoscopy; Best practices in surveillance for Barretts esophagus; Pathologic assessment of Barretts esophagus and Barretts related neoplasia:: Do we need quality indicators; Cost effectiveness of screening, surveillance and endoscopic eradication therapies in Barretts esophagus and early esophageal cancer; Advanced imaging and sampling in Barretts esophagus:: Artificial intelligence to the rescue; Advances in biomarkers for risk stratification in Barretts esophagus; Current status of chemoprevention in Barretts esophagus; Optimizing outcomes with radiofrequency frequency ablation of Barretts esophagus:: candidates, efficacy and durability; Updates in cryotherapy for Barretts esophagus; Role of endoscopic mucosal resection and endoscopic submucosal dissection in the management of Barretts related neoplasia; Practical approach to refractory and recurrent Barretts esophagus; Surgical management of Barretts related neoplasia; and Measuring Quality in Barretts esophagus:: Time to embrace quality indicators. Endoscopists will come away with the information they need to screen, diagnose, and treat patients with Barretts Esophagus.