Now in its third edition, the Oxford Textbook of Endocrinology and Diabetes is an up-to-date, objective and comprehensive text that covers the full scope of endocrinology and diabetes. It contains wide ranging and pragmatic advice on diagnosis and clear guidelines for recommended management, while also covering the scientific principles that underlie the medical practice in this important field.The book has been re-organised into 15 overarching sections, with new sections on Endocrinology of Pregnancy and Management of the Transgender Patient included. All other sections have been extensively updated and restructured. Each chapter is written by an internationally acknowledged expert, relates basic science to evidence based guidelines and clinical management, and where appropriate offers an outline of the controversies in the subject. The textbook has an international focus and dealswith subject matter applicable across the globe.The new edition has over 800 images complementing the extensive text and information provided. The book is a one-stop text for trainees and consultants in Endocrinology and Diabetes, residents, those preparing for sub-specialty exams and other professionals allied to the area who need to gain an understanding of the field. It acts as both a point of reference for the experienced consultant as well as a trusted training resource.Purchase of the print work also includes full access to the online edition of the textbook for the life of the edition.
1. Principles of basic and clinical endocrinology; Endocrine Practice Fundamentals; Hormones and receptors: fundamental considerations; Molecular aspects of hormonal regulation; Endocrinology and evolution: lessons from comparative endocrinology; Hormones Across the Lifespan; Pituitary assessment strategy; Endocrine autoimmunity; Common Features of Endocrine Tumours; Genetic Aspects of Endocrine Disease; Environmental Influences on Endocrine Disease; Endocrinology, sleep and circadian rhythms; Principles of Hormone replacement; Prevention in endocrinology; 2. Pituitary and hypothalamic diseases; Functional anatomy of the hypothalamus and pituitary; The neurohypophysis; Aetiology, pathogenesis, and management of disease of the pituitary; Development of the pituitary and genetic forms of hypopituitarism; Molecular pathogenesis of pituitary tumours; Histopathology of pituitary tumours; Imaging of the pituitary; Hypopituitarism: replacement of adrenal, thyroid, and gonadal axes; Adult growth hormone deficiency; Surgery of pituitary tumours; Pituitary radiotherapy; Prolactinomas and hyperprolactinaemia (including macroprolactinaemia); Acromegaly; Clinically nonfunctioning pituitary tumours and gonadotropinomas; Thyrotropinomas; Pituitary carcinoma; Pituitary incidentalomas; Aetiology, pathogenesis, and management of diseases of the hypothalamus; Hypothalamic dysfunction (hypothalamic syndromes); Craniopharyngiomas; Perisellar tumours including cysts, hamartomas, and vascular tumours; Lymphocytic hypophysitis and other inflammatory conditions of the pituitary; Pineal physiology and pathophysiology, including pineal tumours; 3. The Thyroid; Evaluation of the thyroid patient; The history and iconography relating to the thyroid gland; Biosynthesis, transport, metabolism, and actions of thyroid hormones; Clinical assessment of the thyroid patient; Thyroid function tests and the effects of drugs; Nonthyroidal illness syndrome; Thyroid imaging: nuclear medicine techniques; Thyroid imaging: nonisotopic techniques; Epidemiology of thyroid disease and swelling; Aetiology of thyroid disorders; The complex genetics of thyroid disease; Environmental factors; Iodine deficiency disorders; Radiation-induced thyroid disease; Autoimmune thyroid disease; Thyroiditis; Thyrotoxicosis and related disorders; Clinical assessment and systemic manifestations of thyrotoxicosis; Thyrotoxic periodic paralysis; Thyrotoxic storm; Subclinical hyperthyroidism; Causes and laboratory investigations of thyrotoxicosis; Anti-thyroid drug treatment for thyrotoxicosis; Radio-iodine treatment of hyperthyroidism; Surgery for thyrotoxicosis; Management of Graves hyperthyroidism; Graves orbitopathy and dermopathy; Management of toxic multinodular goitre and toxic adenoma; Management of thyrotoxicosis without hyperthyroidism; Hypothyroidism; Clinical assessment and systemic manifestations of hypothyroidism; Causes and laboratory investigation of hypothyroidism; Myxoedema coma; Subclinical hypothyroidism; Syndromes of Resistance to Thyroid Hormone; Treatment of hypothyroidism; Thyroid lumps; Pathogenesis of nontoxic goitre; Management of nontoxic multinodular goitre; Management of the single thyroid nodule; Pathogenesis of thyroid cancer; Pathology of thyroid cancer; Papillary, follicular, and anaplastic thyroid carcinoma and lymphoma; Medullary thyroid carcinoma; 4. Parathyroid, calcium, and bone metabolism; Parathyroid anatomy, hormone synthesis, secretion, action, and receptors; Hypercalcaemia; Primary hyperparathyroidism; Familial Hypocalciuric Hypercalcemia Types 1-3 and Neonatal Severe Primary Hyperparathyroidism; Hypocalcaemic disorders, hypoparathyroidism, and pseudohypoparathyroidism; Bones and the Kidney-The Practical Conundrum: Distinguishing Between Osteoporosis and the Bone Diseases that Accompany Chronic Renal Failure; Hypercalcaemic and hypocalcaemic syndromes in children; Osteoporosis; Thyroid disorders and bone disease; Paget s disease of bone; Rickets and osteomalacia (acquired and heritable forms); Glucocorticoid-induced osteoporosis; 5. The adrenal gland and endocrine hypertension; Adrenal imaging; Adrenal surgery; Adrenal incidentaloma; Adrenocortical cancer; Genetics of phaeochromocytomas, paragangliomas, and neuroblastoma; Management of phaeochromocytoma and paragagnlioma; Genetics of primary aldosteronism and other steroid-related causes of endocrine hypertension; Management of primary aldosteronism; Cushing s syndrome; Genetics of Adrenal Insufficiency; Management of Adrenal Insufficiency; Genetics of congenital adrenal hyperplasia; Modern management of congenital adrenal hyperplasia and prospects for the future; 6. Neuroendocrine tumours and genetic disorders; Overview and Pathophysiology of Neuroendocrine Neoplasms; Neuroendocrine tumour markers; Carcinoid syndrome ; Lung neuroendocrine tumours; Non-functioning pancreatic neuroendocrine tumours; Gastrinoma; Insulinoma and hypoglycaemia; Glucagonoma; Vasointestinal Polypeptide Secreting Tumours; Somatostatinoma; Imaging neuroendocrine tumours of the gastrointestinal tract/gastroenteropancreatic neuroendocrine tumours (GEP-NET); Multiple endocrine neoplasia type 1; Multiple endocrine neoplasia type 2a and 2b; Familial syndromes and genetic causes of paraganglioma and phaeochromocytoma ; Carney s complex; Molecular and Clinical Characteristics Of the McCune-Albright Syndrome; Cowden syndrome; 7. Growth and development during childhood and adolescence; Growth and its Disorders; Recognising Normal and Disordered Growth; Disorders of the GH-IGF Axis; Short stature in children born small for gestational age; Growth Disorders with no defined aetiology; Tall Stature; Sex Development; Sex Determination and Differentiation; Disorders of Sex Development (DSD) in the newborn; Recognising Normal and Disordered Pubertal Development; Pubertal Delay and Hypogonadism; Precocious Puberty; Transition In Endocrinology; 8. Female endocrinology and pregnancy; Normal female endocrinology and ovarian disorders; Neuroendocrinology of reproduction: the role of hypothalamus and pituitary; Ovarian and uterine development from fetal life to puberty; Menstrual cycle and ovulation; Evaluation of the female patient with suspected reproductive endocrine disorders; Clinical evaluation of patient with suspected reproductive endocrine disorders; Laboratory evaluation; Reproductive endocrine disorders; Disorders of gonadotrophin secreton; Hyperprolactinaemia; Premenstrual syndrome; Polycystic ovary syndrome and other androgen excess disorders; Polycystic ovary syndrome: definitions, phenotypes, prevalence and genetics; Polycystic ovary syndrome: reproductive aspects; Polycystic ovary syndrome: metabolic aspects; Polycystic ovary syndrome: Hirsutism; Female hypogonadism and menopause; Female hypogonadism: premature ovarian insufficiency; Female hypogonadism: Endocrinology of the menopause and hormone replacement therapy; Female infertility; Female Infertility and assisted reproduction; Female infertility: fertility preservation; Hormonal contraception; Hormonal contraception; Exogenous factors and female repoductive health; Exogenous factors and female reproductive health: common extragonadal endocrinopathies affecting reproduction; Exogenous factors and female reproductive health: nutrition and reproduction; Exogenous factors and female reproductive health: envrionment and reproduction; 9. Endocrinology of pregnancy; Endocrine disorders of Pregnancy; General considerations relating to thyroid disease in pregnancy; Management of thyroid disorders before assisted and spontaneous pregnancy; Thyroid disease during pregnancy; Management of thyroid disorders after pregnancy; Thyroid disorders in newborns, infants and children; Pituitary tumours in pregnancy; Other disorders of the pituitary and hypothalamus in pregnancy; Adrenal disease in pregnancy; Endocrine bone disease in pregnancy; Imaging of endocrine disorders in pregnancy; 10. Male Reproductive Endocrinology; Normal male reproductive endocrinology; Endocrine and local regulation of testicular hormone and sperm production; Sex steroid actions in the Male; Evaluation of the male patient with suspected hypogonadism and/or infertility; Clinical evaluation; Endocrine evaluation; Diagnostic Semen analysis; Male reproductive endocrine disorders; Klinefelter s syndrome; Adult Hypogonadism: Aetiology; Etiology of Hypogonadism; Types of Treatments; Gonadotrophin induction of spermatogenesis; Male Hypogonadism: Benefits of Testosterone Treatment; Risks of T Treatment; Management of Idiopathic male infertility; Hypothalamo-pituitary-testicular axis fucntion in systemic diseases and effects of medications; Management of sexual dysfunction; Hormonal male contraception; Gynaecomastia; Exogenous factors and male reproductive health; Environmental influences on male reproductive health; Androgen Misuse and Abuse; 11. Management of the Transgender Patient; Introduction to Transgender and Gender Diverse People; Endocrine Treatment of Transgender Youth; Hormone Therapy in transgender women; Hormone therapy in transgender men; Fertility Options for Transgender Persons ; 12. Endocrine Responses to Systemic Diseases or Substance Use; Endocrinology of systemic disease; The endocrine response to stress; Endocrinology in the critically ill; Hormones and the kidney; The endocrinology of liver disease; Endocrine abnormalities in HIV infection; The endocrinology of anorexia nervosa; Endocrine Complications of Substance Misuse ; Endocrinology and alcohol; Use and abuse of performance-enhancing hormones in sport; Effect of Opioids on Adrenal and Reproductive Endocrinology; 13. Endocrinology of cancer; Endocrine Disorders Caused by Cancer or its Treatment; Metastatic Disease in Endocrine Organs; Paraneoplastic endocrine syndromes; Long-term endocrine sequelae of cancer therapy; Endocrine complications of biological cancer therapies; Hormonal therapy for breast and prostatic cancers; The breast: lactation and breast cancer as an endocrine disease; Endocrine treatment of breast cancer; Hormonal Therapy for Prostate Cancer: Molecular basis of efficacy and therapeutic bypass; 14. Obesity, lipids, and metabolic disorders; Obesity; The Physiology of Bodyweight Regulation; Obesity as a Public Health Problem; Medical Complications of Obesity ; Dietary and Medical Management of Obesity; Metabolic Surgery; Assessment of Obesity in Children; Management of Obesity in Children and Young People; Planning obesity care pathways; Lipoprotein metabolism and dyslipidaemia; Lipoprotein metabolism; Genetic forms of dyslipidaemia; Other metabolic disorders; Hyperinsulinaemic Hypoglycaemia; Autoimmune Hypoglycaemia ; Disorders of carbohydrate metabolism; Haemochromatosis And Other Inherited Diseases Of Iron Metabolism; The porphyrias; 15. Diabetes mellitus; Introduction to Diabetes Mellitus; Physiology of glucose homeostasis; Classification and diagnosis of diabetes mellitus; Aetiopathogenesis and Diagnosis of Type 1 Diabetes; Epidemiology and Public Health; Presentation and Natural History; Pathogenesis; Aetiopathogenesis and Diagnosis of Type 2 Diabetes; Epidemiology and Public Health; Presentation and Natural History; Pathogenesis; Non Type 1, Non Type 2 Diabetes; Diagnosis of non type 1, non type 2 forms of diabetes; Principles of Management of Diabetes; Structured Education; Glucose Monitoring and Sensing; Insulins and insulin delivery devices; Non-insulin glucose lowering agents; Hypoglycaemia in the treatment of diabetes mellitus; Evidence-based Management of Type 1 Diabetes; Strategies for management of type 1 diabetes; Psychological and Behavioural Aspects of Type 1 Diabetes Management; Immunotherapy for type 1 diabetes; Transplantation (islet and solid organ); Evidence-based Prevention and Management of Type 2 Diabetes; Strategies for management of type 2 diabetes; Psychological and Behavioural Aspects of Type 2 Diabetes Management; Type 2 diabetes in different ethnic groups; Prevention of Type 2 Diabetes; Emerging Approaches to Restoring Euglycaemia in Diabetes; Regenerative medicine for diabetes; Closed loop; Emergency and Hospital management of Diabetes; Hyperglycaemic Emergencies; Management of the inpatient with diabetes mellitus; Care of diabetes in ICU and peri-sugery; Specialised Management of Other forms of Diabetes; Monogenic forms of diabetes resulting from beta cell dysfunction; Lipodystrophies and severe insulin resistance; Diabetes Secondary to Pancreatic Disease; Diabetes Secondary to Endocrine Disorders; Diabetes in Pregnancy; Psychiatry and Diabetes; Type 1 diabetes and Psychiatry; Type 2 diabetes and Psychiatry; Microvascular Complications of Diabetes; Pathogenesis of Microvascular Complications; Retinopathy; Diabetic Nephropathy; Diabetic Neuropathy; Macrovascular Disease in Diabetes; Mechanisms of macrovascular disease in diabetes; Macrovascular disease in type 2 diabetes; Macrovascular disease in type 1 diabetes; Diabetic dyslipidaemia; Hypertension in diabetes mellitus; The Diabetic Foot; Modern management of diabetes-related foot disease; Delivery of Diabetes Care; Diabetes service organisation; Health Economics of Diabetes Care and Prevention;
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