An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances indisease susceptibility, diagnosis, prognostication, and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and theapplications now afforded by genomic analysis.
SECTION 1: GENERAL GENOMICS; From Genes to Genome - a Historical Perspective; The Human Genome - Structure and Organization; Human Functional Genomics and Proteomics; Epigenomics and Human Disease; Genomic Perspectives of Human Development; Genetic and Genomic Approaches to Taxonomy of Human Diseases; Genomic Technologies; Nutritional Genomics; Pharmacogenomics: Drug Development, Drug Response and Precision Medicines; SECTION 2: CLINICAL GENOMICS; Clinical Medicine in the Genome Era - An Introduction; Complex Cardiovascular Disorders; Diabetes Mellitus and Obesity; Chronic Renal Disease; Haemostasis and Thrombosis; Disorders of Platelets; Applications in Critical Care Medicine; Seizure Disorders; Neurodegenerative Disorders: Tauopathies and Synucleinopathies; Neuropsychiaric Diseases I: Schizophrenia; Neuropsychiaric Diseases II: Mood Disorders; Asthma and Chronic Obstructive Pulmonary Disease; Inflammatory Bowel Disease; Cancer Genomics: Mechanisms, Diagnosis and Therapeutic Implications; Hematological Malignancies: The Paradigm of Acute Myeloid Leukemia; Infectious Diseases: Susceptibility, Resistance, Response, and Anti-Microbial Therapy; Chronic Inflammatory Disorders; Immunological Disorders; Applications in Clinical Pediatrics; Learning and Behavioural Disorders; Complex Ophthalmic Disorders; Applications in Audiological Medicine; Complex Skin Diseases I: Psoriasis; Complex Skin Diseases II: Atopic Dermatitis; Complex Skin Diseases III: Diseases of the Epidermis and Appendages, Skin Pigmentation and Skin Cancer; Osteoporosis and Related Disorders; Applications in Obstetrics & Gynaecology and Reproductive Medicine; Stem Cell Genomics, Cell-based Therapy and Regenerative Medicine; SECTION 3: HEALTH GENOMICS; Genomics and Global Health; Genetic Testing and Genomic Screening; Ethical Issues in Human Genomics; The Regulation of Human Genomics Research;
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