In this issue of PET Clinics, guest editors Drs. Andrew B. Newberg, Eric Guedj, and Abass Alavi bring their considerable expertise to the topic of Applications of FDG-PET in Central Nervous System Disorders. This issue is the first of four that describes the revolutionary impact of FDG-PET on the day-to-day practice of medicine during the past five decades. Top experts discuss key topics in the areas of Foundations and Normal Brain; Neurodegenerative and Movement Disorders; Epilepsy, Tumors, Structural Damage, Inflammation, and Infection; Psychiatric, Functional, and Subjective Disorders; and Clinical Impact and Future Directions.