In this issue of Endocrinology and Metabolism Clinics, guest editors Drs. Viral N. Shah and Courtney Ackeifi bring their considerable expertise to the topic of Adjunctive Therapies in Type 1 Diabetes. Top experts discuss the latest developments in adjunctive therapies to improve glycemic control, reduce complications, and enhance quality of life for individuals with type 1 diabetes. By targeting mechanisms beyond insulin deficiency-such as insulin resistance, appetite regulation, and renal protection-adjunctive therapies hold promise for delaying disease progression, reducing insulin requirements, and minimizing adverse effects associated with intensive insulin therapy.