This issue of Dermatologic Clinics is divided into three sections::1) drug actions, 2) drug reactions, and 3) drug interactions. The first section discusses the latest advances in antimicrobial therapy, topical immunomodulator therapy, and treatment for hyperpigmentation. The drug reactions section focuses on guidelines related to drug-induced hepatotoxicity and recognition and management of severe drug eruptions and reactions. Finally, the issue concludes with a detailed summary of drug interactions important in dermatoses.