This issue of Dermatologic Clinics captures the latest knowledge on cutaneous receptors and contains articles on such topics as keratinocyte cytokine and chemokine receptors; death receptors and apoptosis; vitamin d receptors; sweat gland (eccrine and apocrine) and sebaceous gland receptors; disorders of cell kinetics and differentiation (psoriasis and others; contact dermatitis; UV light and its interaction with cutaneous receptors; and bacterial and viral skin diseases.