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Williams Hematology, Eighth Edition

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Williams Hematology, 10th Edition (IE)
Williams Hematology, 10th Edition (IE)

Williams Hematology, Eighth Edition

9780071621519
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Description

The landmark hematology reference -- now in full color

A Doodys Core Title for 2015!

5 STAR DOODYS REVIEW!
This edition continues the tradition of providing a comprehensive, updated textbook of hematology. This very worthy objective is spectacularly met by this edition. As a textbook of hematology, this has a broad-based audience -- medical students, residents, fellows, and practitioners (including our allied healthpartners) in virtually every aspect of medicine. The authors and editors are internationally recognized -- in fact, luminaries, in their fields....Williams continues to sustain its unparalleled reputation as THE textbook of hematology. Ive run out of superlatives. Get it.--Doodys Review Service

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. The book begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

Featuring a brand-new full-color presentation, the Eighth Edition of Williams Hematology is extensively revised to reflect the latest views of experts in the field. Two new chapters examine the importance of genomics in hematology and cell therapy for tissue replacement, whereas other chapters have been revised to incorporate the newest clinical approaches to the leukemias and lymphomas, and the application of targeted therapy in the treatment of hematologic disorders.

New to this Edition::

  • Full-color presentation conveniently integrates images of blood and tissue findings where they are cited in the text
  • Two additional chapters, “Genomics and Epigenetics,” and “Regenerative Medicine:: Principles of Multipotential Cell Therapy for Tissue Replacement,” offer insights into the application of genomic and monoclonal therapies to hematology and emphasize their role in improving diagnostic and therapeutic methods
  • Expanded coverage of non-Hodgkin lymphoma includes separate chapters on its constituent diseases, providing an in-depth assessment of the diagnosis and management of these disorders
  • A comprehensive discussion of erythrocytosis and thrombocytosis reviews reactive and malignant forms of myeloproliferation, encompassing new genetic advances in these disorders along with more targeted therapeutic approaches
  • Companion CD includes a large selection of morphologies, illustrations, and drawings from the book, in a presentation-ready PowerPoint format
Product Details
McGraw Hill / Medical
49174
9780071621519
9780071621519

Data sheet

Publication date
2010
Issue number
8
Pages count
2460
Dimensions (mm)
224 x 287
Weight (g)
4086
  • Contributors
    Preface
    PART I: CLINICAL EVALUATION OF THE PATIENT
    1. Initial Approach to the Patient: History and Physical Examination, Marshal A. Lichtman and Ernest Beutler
    2. Examination of Blood Cells, Daniel H. Ryan
    3. Examination of the Marrow, Daniel H. Ryan
    PART II: THE ORGANIZATION OF THE LYMPHOHEMATOPOIETIC TISSUES
    4. Structure of the Marrow and the Hematopoietic Microenvironment, Mark J. Koury and Marshall A. Lichtman
    5. The Organization and Structure of Lymphoid Tissues, Thomas J. Kipps
    PART III: EPOCHAL HEMATOLOGY
    6. Hematology of the Fetus and Newborn, James Palis and George B. Segel
    7. Hematology during Pregnancy, Martha P. Mims and Josef T. Prchal
    8. Hematology in Older Persons, William B. Ershler and Dan L. Longo
    PART IV: MOLECULAR AND CELLULAR HEMATOLOGY
    9. Genetic Principles and Molecular Biology, Ernest Beutler
    10. Genomics and Epigenetics, Lynn B. Jorde
    11. Cytogenetics and Molecular Abnormalities, Lucy A. Godley and Michelle M. Le Beau
    12. Apoptosis, Roberta A. Gottlieb
    13. Cell-Cycle Regulation and Hematologic Disorders, Mathias Schmid and Dennis A. Carson
    14. Signal Transduction Pathways, Kenneth Kaushansky
    15. The Cluster of Differentiation Antigens, Thomas J. Kipps
    16. Hematopoietic Stem Cells, Progenitors, and Cytokines, Kenneth Kaushansky
    17. The Inflammatory Process, Jeffrey S. Warren and Peter A. Ward
    18. Innate Immunity, Bruce Beutler
    19. Dendritic Cells and the Control of Innate Adaptive Immunity, Madhav Dhodapkar and Ralph M. Steinman
    PART V: THERAPEUTIC PRINCIPLES
    20. Pharmacology and Toxicity of Antineoplastic Drugs, Bruce A. Chabner, Jeffrey Barnes, James Cleary, Andrew Lane, Constantine Mitsiades, and Paul Richardson
    21. Principles of Hematopoietic Cell Transplantation, Robert Lowsky and Robert S. Negrin
    22. Treatment of Infections in the Immunocompromised Host, Steven Beutler and Lisa Beutler
    23. Principles of Antithrombotic Therapy, Charles W. Francis and Mark Crowther
    24. Principles of Immune Cell Therapy, Carolina Berger and Stanley R. Riddell
    25. Principles of Vaccine Therapy, Sattva S. Neelapu and Larry W. Kwak
    26. Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications, Bruce C. McLeod
    27. Principles of Gene Transfer for Therapy, Januario E. Castro and Thomas J. Kipps
    28. Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement, Armand Keating
    PART VI: THE ERYTHROCYTE
    29. Morphology of the Erythron, Brian S. Bull and Paul C. Herrmann
    30. Composition of the Erythrocyte, Ernest Beutler
    31. Production of Erythrocytes, Josef T. Prchal
    32. Destruction of Erythrocytes, Ernest Beutler
    33. Clinical Manifestations and Classification of Erythrocyte Disorders, Josef T. Prchal
    34. Aplastic Anemia: Acquired and Inherited, George B. Segel and Marshall A. Lichtman
    35. Pure Red Cell Aplasia, Neal S. Young
    36. Anemia of Chronic Renal Disease, Jaime Caro and Ubaldo Martinez Outschoorn
    37. Anemia of Chronic Disease, Tomas Ganz
    38. Anemia of Endocrine Disorders, Xylina T. Gregg and Josef T. Prchal
    39. The Congenital Dyserythropoietic Anemias, Jean Delaunay
    40. Paroxysmal Nocturnal Hemoglobinuria, Charles J. Parker
    41. Folate, Cobalamin, and Megaloblastic Anemias, Ralph Green
    42. Disorders of Iron Metabolism, Ernest Beutler
    43. Anemia Resulting from Other Nutritional Deficiencies, Ralph Green
    44. Anemia Associated with Marrow Infiltration, Archana M. Agarwal and Josef T. Prchal
    45. The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseaes, Patrick G. Gallagher
    46. Disorders of Red Cells Resulting from Enzyme Abnormalities, Wouter W. van Solinge and Richard van Wijk
    47. The Thalassemias: Disorders of Globin Synthesis, David J. Weatherall
    48. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities, Kavita Natarajan, Tim M. Townes, and Abdullah Kutlar
    49. Methemoglobinemia and Other Dyshemoglobinemias, Neeraj Agarwal and Josef T. Prchal
    50. Hemolytic Anemia Resulting from Physical Injury to Red Cells, Kelty R. Baker and Joel Moake
    51.Hemolytic Anemia Resulting from Chemical and Physical Agents, Brian S. Bull and Paul C. Herrmann
    52. Hemolytic Anemia Resulting from Infections with Microorganisms, Marshall A. Lichtman
    53. Hemolytic Anemia Resulting from Immune Injury, Charles H. Packman
    54. Alloimmune Hemolytic Disease of the Fetus and Newborn, Jayashree Ramasethu and Naomi L. C. Luban
    55. Hypersplenism and Hyposlenism, Jaime Caro and Ubaldo Martinez Outschoorn
    56. Primary and Secondary Polycythemias (Erythrocytosis), Josef T. Prchal
    57. The Porphyrias, John D. Phillips and Karl E. Anderson
    58. Hereditary and Acquired Sideroblastic Anemias, Prem Ponka and Josef T. Prchal
    PART VII: NEUTROPHILS, EOSINOPHILS, BASOPHILS, AND MAST CELLS
    59. Morphology of Neutrophils, Eosinophils, and Basophils, C. Wayne Smith
    60. Composition of Neutrophils, C. Wayne Smith
    61. Production, Distribution, and Fate of Neutrophils, C. Wayne Smith
    62. Eosinophils and Their Disorders, Andrew J. Wardlaw
    63. Basophils and Mast Cells and Their Disorders, Stephen J. Galli, Dean D. Metcalfe, Daniel A. Arber, and Ann M. Dvorak
    64. Classification and Clinical Manifestations of Neutrophil Disorders, Marshall A. Lichtman
    65. Neutropenia and Neutrophilia, David C. Dale
    66. Disorders of Neutrophil Function, Niels Borregaard and Laurence A. Boxer
    PART VIII: MONOCYTES AND MACROPHAGES
    67. Morphology of Monocytes and Macrophages, Steven D. Douglas and Florin Tuluc
    68. Biochemistry and Functions of Monocytes and Macrophages, Annette Pluddemann and Siamon Gordon
    69. Production, Distribution, and Fate of Monocytes and Macrophages, Siamon Gordon and Annette Pluddemann
    70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages, Marshall A. Lichtman
    71. Monocytosis and Monocytopenia, Marshall A. Lichtman
    72. Inflammatory and Malignant Histiocytosis, Kenneth L. McClain and Carl E. Allen
    73. Lipid Storage Diseases, Ari Zimran and Deborah Elstein
    PART IX: LYMPHOCYTES AND PLASMA CELLS
    74. Morphology of Lymphocytes and Plasma Cells, H. Elizabeth Broome
    75. Composition and Biochemistry of Lymphocytes and Plasma Cells, Thomas J. Kipps
    76. Lymphopoiesis, Gay M. Crooks
    77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production, Thomas J. Kipps
    78. Functions of T Lymphocytes: T-Cell Receptors for Antigen, Thomas J. Kipps
    79. Functions of Natural Killer Cells, Giorgio Trinchieri and Lewis L. Lanier
    80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders, Thomas J. Kipps
    81. Lymphocytosis and Lymphocytopenia, Thomas J. Kipps
    82. Immunodeficiency Diseases, Hans D. Ochs and Luigi D. Notarangelo
    83. Hematologic Manifestations of Acquired Immunodeficiency Syndrome, Erin Gourley Reid
    84. Mononucleosis Syndromes, Robert F. Betts
    PART X: NEOPLASTIC MYELOID DISEASES
    85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders, Marshall A. Lichtman
    86. Polycythemia Vera, Josef T. Prchal and Jaroslav F. Prchal
    87. Essential Thrombocythemia, Philip A. Beer and Anthony R. Green
    88. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia), Jane L. Liesveld and Marshall A. Lichtman
    89. Acute Myelogenous Leukemia, Jane L. Liesveld and Marshall A. Lichtman
    90. Chronic Myelogenous Leukemia and Related Disorders, Jane L. Liesveld and Marshall A. Lichtman
    91. Primary Myelofibrosis, Marshall A. Lichtman and Ayalew Tefferi
    PART XI: NEOPLASTIC LYMPHOID DISEASES
    92. Classification of Malignant Lymphoid Disorders, Thomas J. Kipps and Huan-You Wang
    93. Acute Lymphoblastic Leukemia, Ching-Hon Pui
    94. Chronic Lymphocytic Leukemia and Related Diseases, Thomas J. Kipps
    95. Hairy Cell Leukemia, Darren Sigal and Alan Saven
    96. Large Granular Lymphocytic Leukemia, Thomas P. Loughran and Marshall E. Kadin
    97. General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodel Disease, Kenneth A. Foon and Marshall A. Lichtman
    98. Pathology of Malignant Lymphomas, Randy D. Gascoyne and Kenneth A. Foon
    99. Hodgkin Lymphoma, Sandra J. Horning
    100. Diffuse Large B-Cell Lymphoma, Michael Boyiadzis and Kenneth A. Foon
    101. Follicular Lymphoma, Oliver W. Press
    102. Mantle Cell Lymphoma, Jorge E. Romaguera and Peter W. McLaughlin
    103. Marginal Zone B-Cell Lymphomas, Emanuele Zucca
    104. Burkitt Lymphoma, Jonathan W. Friedberg and Archibald S. Perkins
    105. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome), Larisa J. Geskin
    106. Mature T-Cell and Natural Killer Cell Lymphomas, Oscar B. Goodman, Jr. and Nam H. Dang
    107. Plasma Cell Neoplasms: General Considerations, H. Elizabeth Broome
    108. Essential Monoclonal Gammopathy, Marshall A. Lichtman
    109. Myeloma, Frits van Rhee, Elias Anaissie, Edgardo Angtuaco, Twyla Bartel, Joshua Epstein, Bijay Nair, John Shaughnessy, Shmuel Yaccoby, and Bart Barlogie
    110. The Amyloidoses, Vaishali Sanchorawala, Daniel R. Jacobson, David C. Seldin, and Joel N. Buxbaum
    111. Macroglobulinemia, Steven P. Treon and Giampaolo Merlini
    112. Heavy-Chain Disease, Dietlind L. Wahner-Roedler and Robert A. Kyle
    PART XII: HEMOSTATIS AND THROMBOSIS
    113. Megakaryopoiesis and Thrombopoiesis, Kenneth Kaushansky
    114. Platelet Morphology, Biochemistry, and Function, Susan S. Smyth, Sidney Whiteheart, Joseph E. Italiano, Jr. and Barry S. Coller
    115. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostatis, Dougald M. Monroe, III, Maureane Hoffman, and Harold R. Roberts
    116. Control of Coagulation Reactions, John H. Griffin
    117. Vascular Function in Hemostatis, Katherine A. Hajjar, Aaron J. Marcus, and William Muller
    118. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostatis, Uri Seligsohn and Kenneth Kaushansky
    119. Thrombocytopenia, Reyhan Diz-Kucukkaya, Junmei Chen, Amy Geddis, and Jose A. Lopez
    120. Reactive Thrombocytosis, Kenneth Kaushansky
    121. Hereditary Qualitative Platelet Disorders, Barry S. Coller, Deborah L. French, and A. Koneti Rao
    122. Acquired Qualitative Platelet Disorders, Charles S. Adams, Sanford J. Shattil, and Joel S. Bennett
    123. The Vascular Purpuras, Doru T. Alexandrescu and Richard L. Gallo
    124. Hemophilia A and Hemophilia B, Harold R. Roberts, Nigel S. Key, adn Miguel A. Escobar
    125. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors, Uri Seligsohn, Ariella Zivelin, and Ophira Salomon
    126. Hereditary Fibrinogen Abnormalities, Marguerite Neerman-Arbez and Philippe de Moerloose
    127. Von Willebrand Disease, Jill Johnsen and David Ginsburg
    128. Antibody-Mediated Coagulation Factor Deficiencies, Pete Lollar
    129. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation, Ton Lisman and Philip G. De Groot
    130. Disseminated Intravascular Coagulation, Marcel Levi and Uri Seligsohn
    131. Hereditary Thrombophilia, Uri Seligsohn and Aharon Lubetsky
    132. The Antiphospholipid Syndrome, Jacob H. Rand
    133. Antibody-Mediated Thrombotic Disorders: Thrombotic-Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia, J. Evan Sadler and Mortimer Poncz
    134. Venous Thrombosis, Gary E. Raskob, Russell D. Hull, and Graham F. Pineo
    135. Atherothrombosis: Disease Initiation, Progression, and Treatment, Emile R. Mohler III and Andrew I. Schafer
    136. Fibrinolysis and Thrombolysis, Katherine A. Hajjar and Jia Ruan
    PART XIII: TRANSFUSION MEDICINE
    137. Erythrocyte Antigens and Antibodies, Marion E. Reid
    138. Human Leukocyte and Platelet Antigens, Myra Coppage, David Stroncek, Janice McFarland, and Neil Blumberg
    139. Blood Procurement and Screening, Jeffrey McCullough
    140. Red Cell Transfusion, Norma B. Lerner, Majed A. Rafaai, and Neil Blumberg
    141. Preservation and Clinical Use of Platelets, Mike Murphy and Ralph Vassallo
    Index

See next edition:

Williams Hematology, 10th Edition (IE)
Williams Hematology, 10th Edition (IE)
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