Animal research has contributed greatly to our understanding of the special capability of the frontal lobes to respond to a variety of input from lower order sensory and posterior association cortex and this and other observations are reported in this volume. Findings that functions dependent on the frontal lobes emerge late in ontogeny and appear to decline early in normal aging are reviewed and their implications for neuropsychology are discussed. In this volume the concept of working memory is discussed in relationship to both functional neuroimaging and patient studies. Gross distinctions in the functioning of the prefrontal cortex have divided it topographically into dorsolateral and ventromedial sectors. Chapters highlighting the role of the dorsolateral and ventromedial sectors from both neuroimaging and lesion perspectives are also included. Computational modeling has taken center-stage in cognitive neuroscience and its usefulness in testing different theoretical stances about the role of the frontal lobes in information processing is presented.
Preface. List of contributors. 1. Anatomic basis of functional specialization in prefrontal cortices in primates (H. Barbas, H.T. Ghashghaei, N.L. Rempel-Clower, D. Xiao). 2. The prefrontal cortex: conjunction and cognition (E.K. Miller, W.F. Asaad). 3. Working memory: Findings from neuroimaging and patient studies (E.E. Smith, C. Marshuetz, A. Geva). 4. Age, cognition and emotion (L. Phillips, S. McPherson, S. Della Sala). 5. The frontal lobes and frontal-subcortical circuits in neuropsychiatric disorders (S. McPherson, J.L. Cummings). 6. The somatic marker hypothesis and decision-making (A. Bechara, D. Tranel, A.R. Damasio). 7. Neuropsychological consequences of dysfunction in human dorosolateral prefrontal cortex (S.W. Anderson, D. Tranel). 8. The human prefrontal cortex has evolved to represent components of structured event complexes (J. Grafman). 9. The processing of temporal information in the frontal lobe (P. Nichelli). 10. Neural network models of prefrontal cortex and cognitive control (J.D. Cohen). Subject index.
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