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The Lancet Handbook of Essential Concepts in Clinical Research

The Lancet Handbook of Essential Concepts in Clinical Research

9780080448664
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Description
Building on articles previously published in The Lancet, this handbook is essential for busy clinicians and active researchers interested in research methods in epidemiology.

The needs of clinicians predominate throughout the text, but these needs overlap with those of researchers especially in chapters covering randomized controlled trials. For readers to assess trials accurately they need to understand relevant guidelines on the conduct of trials that are emerging from methodological research. In presenting these discussions to clinicians these chapters will help researchers who also do randomized trials and provide a methodological background that enhances the quality and quantity of their research productivity.
Product Details
Lancet
36927
9780080448664
9780080448664

Data sheet

Publication date
2006
Issue number
1
Cover
paperback
Pages count
242
Dimensions (mm)
187 x 235
Weight (g)
280
  • An overview of clinical research:: the lay of the land.
    Descriptive studies:: what they can and cannot do.
    Bias and causal associations in observational research.
    Cohort studies:: marching towards outcome.
    Case-control studies:: research in reverse.
    Generation of allocation sequences in randomized trials:: chance, not choice.
    Allocation concealment in randomized trials:: defending against deciphering.
    Sample size slippages in randomized trials:: exclusions and the lost and wayward.
    Blinding in randomized trials:: hiding who got what.
    Uses and abuses of screening tests.
    Unequal group sizes in randomized trials:: guarding against guessing.
    Sample size calculations in randomized trials:: mandatory and mystical.
    Compared to what? Finding controls for case-control studies.
    Refining clinical diagnosis with likelihood ratios.
    Multiplicity in randomized trials I:: endpoints and treatments.
    Multiplicity in randomized trials II:: subgroup and interim analyses.
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