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Written by the world’s foremost authorities, this volume provides comprehensive coverage of current approaches to the prevention, diagnosis, and management of atherothrombosis and its coronary and noncoronary complications. This edition has been thoroughly updated, sharply focused on clinical information, and trimmed to one manageable volume.
Coverage begins with a review of risk factors and prevention, emphasizing lipid abnormalities, hypertension, smoking, diabetes, and obesity. Subsequent sections examine the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, chronic stable angina, and noncoronary atherothrombosis. Clinical presentations, medical management, and the latest interventional strategies are included.
Data sheet
Ch 1 A Historical Perspective on Atherothrombosis and Coronary Artery Disease
W. Bruce Fye
Ch 2 Incidence, Prevalence, and Mortality of Coronary Artery Disease
William B. Kannel
Section I Major Risk Factors and Primary Prevention
Ch 3 Overview
Henry C. McGill, Jr. and C. A. McMahan
Ch 4 Lipids, Nutrition, and Coronary Heart Disease
Scott M. Grundy
Ch 5 Genetic Dyslipoproteinemias
H. Brian Brewer, Jr. and Silvia Santamarian-Fojo
Ch 6 Structure and Function of the Plasma Lipoproteins and Their Receptors
John P. Kane
Ch 7 Plasma High Density Lipoproteins and Atherogenesis
Daniel Rader
Ch 8 Oxidized Lipoproteins and Atherosclerosis
Guy M. Chisolm
Ch 9 Lipoprotein
Angelo M. Scanu
Ch 10 Clinical Classifications
Thomas P. Bersot and Robert W. Mahley
Ch 11 Management and ATP III Guidelines
John A. Farmer and Antonio M. Gotto, Jr.
Ch 12 Impact of Management in Stabilization and Decrease in Cardiovascular Events
B. Greg Brown and Antonio M. Gotto, Jr.
Ch 13 Genetics and Mechanisms of Hypertension
Steven C. Hunt and Paul N. Hopkins
Ch 14 Renin Angiotensin System and Atherothrombotic Vascular Disease
Victor J. Dzau and Aram V. Chobanian
Ch 15 Clinical Classifications of Hypertension
Edward D. Frohlich
Ch 16 Management of Hypertension
Norman M. Kaplan
Ch 17 Hypertensive Heart Disease
Robert A. Phillips and Joseph A. Diamond
Ch 18 Cigarette Smoking and Atherothrombosis
Thomas Pickering and Lynn Clemow
Ch 19 Diabetes, Obesity, and the Metabolic Syndrome
Doron Aronson and Elliot J. Rayfield
Ch 20 Hormonal Replacement:: Pros and Cons
Lori Mosca
Ch 21 Vitamins:: Pros and Cons
Joan E. B. Fox
Section II Pathogenesis of Atherosclerosis
General Principles
Ch 22 Developmental Biology of the Vasculature
Margaret Kirby
Ch 23 Vasculogenesis
Peter Carmeliet
Ch 24 Embryogenesis of the Vascular System
Brant Weinstein
Ch 25 Mouse Models of Lipoprotein and Atherothrombosis
Andrew Plump
Ch 26 Genetics of Atherothrombotic Disease
Pierre Zoldhelyi
Ch 27 Vascular Endothelium
Paul E. DiCorleto
Ch 28 Role of Alterations in the Differentiated State of Smooth Muscle Cell in Atherothrombogenesis
Gary K. Owens
Ch 29 The Vascular Extracellular Matrix
Thomas N. Wight
Ch 30 The Histological Classification of Atherosclerotic Lesions
Herbert C. Stary