In this issue of Thoracic Surgery Clinics, guest editors Drs. Mara B. Antonoff and Smita Sihag bring their considerable expertise to the topic of Pulmonary Metastasectomy. Top experts provide articles on the most common pulmonary metastasectomies (colorectal cancer, renal cell carcinoma, sarcoma, melanoma, and head and neck cancer), along with articles on hybrid approaches to local management, transcontinental differences in management, disparities, quality of life, and reoperative pulmonary metastasectomy.