The study of amino acids and peptides is becoming increasingly important to chemists becuase of the growing overlap of mainstream organic chemistry with bioorganic chemistry and biochemistry. This introductory text begins with a brief survey of the role and diversity of amino acids, peptides, and proteins in nature, and goes on to describe and explain the principal methods of chemical synthesis. With its emphasis on chemical principles and strategies rather than detailed technicalmatters, the book will be essential reading for all students of chemistry and biochemistry with an interest in this important field. This second edition contains extensive additions and adjustments, to present a completely up-to-date account of the chemical essentials of mainstream peptidesynthesis.
Introduction; a-Amino acid synthesis; a-Amino protection; a-Carboxy protection; Peptide bond formation; Residue-specific considerations; Strategy and tactics; Solution peptide synthesis; Solid phase peptide synthesis; GFP, a tour de force; Appendix A Abbreviations and their use; Appendix B Further reading and general sources; Index;
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