Optogenetics: From Neuronal Function to Mapping and Disease Biology

Authors:

Krishnarao Appasani

Brand: Cambridge University Press

ISBN: 9781107053014

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Description

Discovered little more than a decade ago, optogenetics - a revolutionary technique combining genetic and optical methods to observe and control the function of neurons - is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinsons disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.

Product Details

Brand Cambridge University Press

Reference 66614

EAN13 9781107053014

ISBN 9781107053014

Data sheet

Publication date: 2017
Issue number: 1
Cover: hard cover
Pages count: 502
Dimensions (mm): 179.00 x 253.00
Weight (g): 1200

List of contributors; Foreword; Preface; List of abbreviations; Part I. Optogenetics in Model Organisms:: 1. Introduction to optogenetics:: from neuronal function to mapping and disease biology; 2. Uncovering key neurons for manipulation in mammals; 3. From connectome to function:: using optogenetics to shed light on the Caenorhabditis elegans nervous system; 4. From synapse to behaviour:: optogenetic tools for investigation of the Caenorhabditis elegans nervous system; 5. Using optogenetics in vivo to stimulate regeneration in Xenopus laevis; Part II. Opsin Biology, Tools and Technology Platform:: 6. Sodium and engineered potassium light-driven pumps; 7. Simultaneous electrophysiology and optogenetic stimulation methods; 8. Role of electrical activity in horizontal axon growth in the developing cortex:: a time-lapse study using optogenetic stimulation; 9. Development of an optogenetic tool to regulate protein stability in vivo; 10. Photo-activatable nucleotide cyclases for synthetic photobiology applications; 11. Bioluminescence activation of light-sensing molecules; Part III. Optogenetics in Neurobiology, Brain Circuits and Plasticity:: 12. Optogenetics for neurological disorders:: what is a path to the clinic?; 13. Optogenetic control of astroglia; 14. Optogenetics for neurohormones and neuropeptides:: focus on oxytocin; 15. Optogenetic approaches to investigate brain circuits; 16. Optogenetic mapping of neuronal connections and their plasticity; Part IV. Optogenetics in Learning, Neuro-psychiatric Diseases and Behavior:: 17. Optogenetics to study reward learning and addiction; 18. Optogenetics and the dissection of neural circuits underlying depression and substance-use disorders; 19. Optogenetics research in behavioral neuroscience:: insights into the brain basis of reward learning and goal-directed behavior; 20. An optogenetic approach to treat epilepsy; 21. Using optogenetics and stem cells-derived neural engraftment techniques to restore lost motor function; Part V. Optogenetics in Vision Restoration and Memory:: 22. Optogenetics in treating retinal disease; 23. Optogenetics for vision recovery:: from traditional to designer optogenetic tools; 24. A promise of vision restoration; 25. Holographic Optical Neural Interfacing (HONI) with retinal neurons; 26. Strategies for restoring vision by transducing a channelrhodopsin gene into retinal ganglion cells; 27. Optogenetic dissection of a top-down prefrontal-to-hippocampus memory circuit; Part VI. Optogenetics in Sleep, Prosthetics and Epigenetics of Neurodegenerative Diseases:: 28. Optogenetic dissection of sleep-wake control:: evidence for a thalamic control of sleep architecture; 29. Optogenetics and auditory implants; 30. Optogenetic stimulation for cochlear prosthetics; 31. The role of amino acids in neurodegenerative and addictive diseases; 32. Applications of combinations of deep brain stimulation and optogenetics:: ethical considerations:: an epilogue.

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