In this issue of Critical Care Clinics, guest editors Drs. Yahya Shehabi, Joanna L. Stollings, and Timothy D. Gerard bring their considerable expertise to the topic of Optimizing Sedation and Analgesia in the ICU. Top experts cover key issues such as the role of antipsychotic agents for adjunct sedation; analgesia first for every patient:: current concepts in critical illness; monitoring sedation depth in critical illness; inhalational agents as ICU sedatives; and much more.